Calcium ion coordinated dexamethasone supramolecular hydrogel as therapeutic alternative for control of non-infectious uveitis

Acta Biomaterialia
Wei WuXingYi Li

Abstract

Supramolecular hydrogels formed by the self-assembly of therapeutic agents have received considerable attention due to their high drug payload and carrier-free features. Herein, we constructed a dexamethasone sodium phosphate (Dex) supramolecular hydrogel in combination with Dex and calcium ion (Ca2+) and further demonstrated its therapeutic efficacy in the control of ocular inflammation. The developed supramolecular hydrogel was thoroughly characterized by rheology, TEM, FTIR and XRD. Calcium ions and Dex concentration had a marked influence on the sol-gel transition behaviour of hydrogel and the proposed Dex supramolecular hydrogel displayed thixotropic properties. The drug release rate from Dex supramolecular hydrogel was dependent on the Ca2+ concentration. In comparison with Dex aqueous solution, single intravitreal injections of Dex supramolecular hydrogel up to 30μg/eye were well tolerated without causing undesirable complications of fundus blood vessel tortuosity and lens opacity, as indicated by electroretinograms (ERGs), fundus photography and histopathology. Moreover, the administration by Dex supramolecular hydrogel exhibited a comparable anti-inflammatory efficacy to native Dex solution on an experimental autoimmun...Continue Reading

References

Apr 1, 2009·Journal of the American Chemical Society·Harunobu KomatsuItaru Hamachi
Feb 6, 2013·Journal of the American Chemical Society·Andrew G CheethamHonggang Cui
Jan 13, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Viet Anh Nguyen HuuAdah Almutairi

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Citations

Apr 27, 2019·Macromolecular Bioscience·Deqing LinXingyi Li
Mar 11, 2020·Frontiers in Chemistry·Hui LiuYuqin Wang
Feb 10, 2021·Advanced Drug Delivery Reviews·Stéphane Bernhard, Mark W Tibbitt
Jan 16, 2020·Bioconjugate Chemistry·Xiaotong ChengGaolin Liang
Apr 13, 2021·International Journal of Pharmaceutics·Xueqi LinWen Xu
May 21, 2021·Advanced Drug Delivery Reviews·Zhenghao ZhangXingyi Li
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Guihua FangBo Tang
Aug 10, 2021·Frontiers in Molecular Biosciences·Yun HaoLuo Zhang

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