Calcium ionophore and acetylcholine dilate arterioles on the mouse brain by different mechanisms

Stroke; a Journal of Cerebral Circulation
W I RosenblumB Wormley

Abstract

Pial arterioles on the surface of the mouse brain were observed in vivo under a chamber with a glass window. When placed under the window, calcium ionophore, acetylcholine, and previously acidified sodium nitrite each dilated the arterioles. If the cyclooxygenase inhibitors indomethacin or acetylsalicylic acid were first placed in the chamber, subsequent dilation of the arterioles by calcium ionophore was reduced to essentially zero. Similar blockade of cyclooxygenase failed to significantly reduce dilation by acetylcholine or sodium nitrite. We have previously shown that dilations by calcium ionophore and acetylcholine were endothelium dependent. Our present experiments show that the endothelium-dependent mechanism for dilation by calcium ionophore is cyclooxygenase dependent, while that for acetylcholine is not. This implies that, in pial arterioles, the endothelium-derived relaxing factor for acetylcholine differs from that for calcium ionophore. This agrees with data from other microvascular beds.

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Citations

Jan 1, 1992·Pharmacology & Therapeutics·F M Faraci
Jan 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Laibaik ParkCostantino Iadecola
Dec 1, 1992·Clinical and Experimental Pharmacology & Physiology·C C WuM H Yen
Dec 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K NiwaC Iadecola
Mar 28, 2012·Journal of Pharmacological Sciences·Hiroki FujiwaraHiromu Kawasaki
Jul 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W I RosenblumG H Nelson
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W M ArmsteadC W Leffler
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Benedek ErdösDavid W Busija
Mar 8, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Guang YangCostantino Iadecola
Jun 28, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jean-Marc BugnicourtJean-Marc Chillon

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