Calcium, magnesium and phosphate during and after hypothermic cardiopulmonary bypass without temperature correction of acid base status

Acta Anaesthesiologica Scandinavica
C B KancirD Stokke

Abstract

The plasma concentration variations of calcium, magnesium and phosphate were studied in ten patients during and after hypothermic cardiopulmonary bypass (CPB) without temperature correction of acid base status. During the study, pH remained stable, but all the other studied components varied significantly (P less than 0.001). At the start of CPB, the mean ionized calcium concentration increased 25%, and magnesium and phosphate decreased 29% and 40%, respectively, from their control values. At the end of blood cooling, ionized calcium was still 11% above its initial value, magnesium 50% above, and phosphate 39% below. Before weaning from CPB, ionized calcium remained 10% above its initial level, magnesium 41% above, and phosphate 26% below. After CPB, the different divalent ions returned to their initial levels within 1 h for ionized calcium, 6 h for phosphate and 9 h for magnesium. One day post-CPB, ionized calcium was at its start level, magnesium 13% lower, and phosphate 36% higher. During cardiac surgery, the acid base regulation without temperature correction (so-called "alpha stat mode") avoided the appearance of carbon dioxide acidosis. There were widespread disturbances of the divalent ions concentrations, due principall...Continue Reading

References

Nov 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·K O Pedersen
Sep 1, 1978·British Journal of Anaesthesia·R N WesthorpeJ Lumley
Apr 1, 1987·Canadian Journal of Physiology and Pharmacology·G A Langer
May 1, 1987·Acta Anaesthesiologica Scandinavica·C B KancirJ Wandrup
Jul 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C B KancirJ Wandrup
Feb 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·J WandrupB Nørgaard-Pedersen
Sep 1, 1982·Scandinavian Journal of Clinical and Laboratory Investigation·J ThodeO Siggaard-Andersen
Jan 1, 1981·Intensive Care Medicine·A B Davies, P A Poole-Wilson

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Citations

Sep 1, 1993·Pflügers Archiv : European journal of physiology·V Alfaro, L Palacios
Jan 1, 1993·Critical Reviews in Clinical Laboratory Sciences·G J Kost
Sep 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·C B KancirT Madsen

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