PMID: 2492747Feb 1, 1989Paper

Calcium, magnesium, and phosphorus metabolism in dogs given intravenous triacetin

The American Journal of Clinical Nutrition
J W BaileyJ M Miles

Abstract

Previous studies suggested that acetate in parenteral solutions may adversely affect mineral metabolism by causing sequestration of inorganic phosphate and calcium in the liver. In this study, triacetin, a short-chain triglyceride of acetate and a potential parenteral nutrient, was infused for 3 h at an isocaloric rate in mongrel dogs (n = 6) to test its effects on serum phosphorus, calcium, and magnesium metabolism. There was no change in serum P or Ca. The serum Mg concentration decreased from 0.7 +/- 0.03 to 0.57 +/- 0.03 mmol/L (p less than 0.001) by 90 min and remained at this level for the remainder of the study. The triacetin infusion did not influence fractional urinary Mg excretion; thus, the decrease in serum Mg was likely because of an increase in cellular transport of this cation. A short-chain triglyceride administered to dogs at a rate approximating resting energy expenditure has no demonstrable adverse effects on mineral metabolism.

Citations

Jan 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·J W BaileyJ M Miles
Mar 1, 1995·The American Journal of Physiology·J LeclercH Brunengraber

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