Calcium-mediated metabolic stimulation of neuroendocrine structures by intraventricular endothelin-1 in conscious rats

Brain Research
P M GrossD F Weaver

Abstract

We examined the hypothesis that the vascular- and brain-derived peptide, endothelin-1 (ET), would affect cerebral neuroendocrine structures when administered via the peripheral circulation or via a lateral cerebral ventricle (i.c.v.). ET was infused intravenously (14 nmol/min) or injected i.c.v. (9 pmol) in conscious rats in which local cerebral glucose metabolism was assessed by the quantitative autoradiographic [14C]deoxyglucose technique. Whereas intravenously infused ET was previously demonstrated to selectively stimulate metabolic activity in the pituitary intermediate and anterior lobes of conscious rats, it was without effect in 20 individual structures or subnuclei involved in neuroendocrine functions, including several circumventricular organs. Intraventricular ET, however, caused hypermetabolic responses in 9 neuroendocrine structures, including the pineal gland, subfornical organ, median eminence, the hypothalamic paraventricular and supraoptic nuclei, and other hypothalamic and preoptic structures. The metabolic stimulation resulting from central ET was abolished or attenuated regionally by i.c.v. pretreatment with the calcium L-channel inhibitor, nimodipine. The findings indicate that i.c.v. ET elicits a calcium-me...Continue Reading

References

Sep 16, 1992·Biochemical and Biophysical Research Communications·W K Samson
Jan 1, 1992·Neuron·D S Bredt, S H Snyder
Jan 20, 1992·Brain Research·K M WallA V Ferguson
Jun 1, 1990·Trends in Neurosciences·C A RossS H Snyder
Jan 1, 1991·Journal of Hypertension·M NishimuraM Yoshimura
Mar 1, 1991·Endocrinology·W K SamsonF L Huang
Jan 1, 1991·Regulatory Peptides·A V Ferguson, P Smith
Jan 26, 1990·Science·T YoshizawaI Kanazawa
Sep 29, 1989·Biochemical and Biophysical Research Communications·M ShichiriF Marumo
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 1, 1980·Canadian Journal of Physiology and Pharmacology·N W KastingK E Cooper

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Citations

Jan 29, 2000·Archives of Physiology and Biochemistry·M D Garrido, A Israel

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