Calcium-mediated parathyroid hormone release changes in patients treated with the calcimimetic agent cinacalcet

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Angel L M de FranciscoM Arias

Abstract

The parathyroid-calcium (Ca(2+)-PTH) curve expresses modulation of parathyroid hormone (PTH) secretion by the parathyroid gland as a function of changing extracellular Ca(2+) concentration. Patients with hyperparathyroidism (HPT) show a rightward shift of the curve compared with controls, suggesting a reduced sensitivity of parathyroid cells to Ca(2+). Increasing the sensitivity of the parathyroid gland to extracellular Ca(2+) by manipulation of the Ca(2+)-sensing receptor (CaR) may have therapeutic potential. Calcimimetics allosterically modify CaR and render it more sensitive to extracellular Ca(2+), accounting for the simultaneous reduction of Ca(2+) and PTH seen in most patients. The Ca(2+)-PTH curve was evaluated in 10 haemodialysis patients, with baseline intact PTH levels >300 pg/ml in two haemodialysis sessions, one before and the other after (range, 9-22 weeks) cinacalcet treatment. In each session a 2-h low-dialysate Ca(2+) concentration was used to induce hypocalcaemia and maximally stimulate PTH secretion, followed immediately by a 2-h high-dialysate Ca(2+) concentration to induce hypercalcaemia and maximally inhibit PTH secretion. Significant decreases in ionized Ca(2+) and intact PTH were observed following cinaca...Continue Reading

References

Nov 1, 1991·Journal of the American Society of Nephrology : JASN·M RodriguezF Llach
Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A J FelsenfeldF Llach
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M CloutierP D'Amour
Apr 15, 1993·Nature
Apr 1, 1993·Kidney International·A J Felsenfeld, F Llach
May 1, 1993·Kidney International·J T KwanJ Cunningham
Nov 1, 1995·Journal of the American Society of Nephrology : JASN·A J FelsenfeldM Rodriguez
Mar 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M J BorregoM Rodriguez
Mar 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M RodriguezA J Felsenfeld
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·E F NemethM F Balandrin
Dec 16, 1998·Kidney International·A L de FranciscoM Rodriguez
Oct 21, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F MalbertiE Imbasciati
Nov 26, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C EstepaA J Felsenfeld
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·William G GoodmanJack W Coburn
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Matthias KretzlerHermann-Josef Gröne
Feb 22, 2003·Journal of the American Society of Nephrology : JASN·L Darryl QuarlesDavid A Bushinsky
Oct 9, 2003·Kidney International·Rafael SantamariaMariano Rodriguez
Nov 1, 2003·The Journal of Pharmacology and Experimental Therapeutics·Edward F NemethDavid Martin

❮ Previous
Next ❯

Citations

Dec 17, 2010·Calcified Tissue International·Francisco J MendozaEscolastico Aguilera-Tejero
Oct 30, 2008·Nature Clinical Practice. Nephrology·James B Wetmore, L Darryl Quarles
Aug 30, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicola Giotta, Angela Marino
Jun 21, 2011·Seminars in Dialysis·Jason R Stubbs, James B Wetmore
Dec 12, 2012·American Journal of Physiology. Renal Physiology·M Cecilia Ortiz-CapisanoWilliam H Beierwaltes
Jan 6, 2011·Journal of Postgraduate Medicine·E Gonzalez-ParraA Ortiz
Jun 8, 2013·Néphrologie & thérapeutique·Pierre DelanayeEtienne Cavalier
Feb 12, 2011·Néphrologie & thérapeutique·Pablo Urena Torres
Nov 30, 2010·Néphrologie & thérapeutique·Mouna HamoudaMezri Elmay
Apr 18, 2009·Seminars in Nephrology·Mark E Williams
Aug 27, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Francisco José Borrego UtielMaría Auxiliadora Mazuecos Blanca
Apr 28, 2012·Hemodialysis International·Mouna HamoudaMezri Elmay
Jan 25, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Anders NordholmEwa Lewin
Aug 8, 2015·Clinical Kidney Journal·Guillaume JeanCharles Chazot
Dec 6, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Tilman B Drüeke, Eberhard Ritz
Apr 14, 2009·The International Journal of Artificial Organs·Jordi BoverJosé Ballarin
Jun 1, 2013·Clinical Kidney Journal·Antonio Bellasi, Mario Cozzolino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society of Nephrology : JASN
Casimiro VallePedro Aljama
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
P UrenãDenis Fouque
The Journal of Pharmacology and Experimental Therapeutics
Edward F NemethDavid Martin
The New England Journal of Medicine
Geoffrey A BlockWilliam G Goodman
© 2022 Meta ULC. All rights reserved