PMID: 18407217Aug 1, 1994Paper

Calcium mobilization by inositol phosphates and other intracellular messengers

Trends in Endocrinology and Metabolism : TEM
J W Putney, G S Bird

Abstract

Inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] is now widely recognized as a messenger controlling the release of calcium from intracellular stores. In oocytes, and also probably in excitable cells, another potential calcium-mobilizing messenger is cyclic ADP ribose, although there is as yet little evidence that its levels are regulated by hormones or other extracellular mediators. In addition to signaling intracellular calcium release, [Ins(1,4,5)P(3)] also regulates calcium entry across the plasma membrane, but not in a direct manner. Rather, the depletion of intracellular stores by the calcium-mobilizing action of [Ins (1,4,5)P(3)] initiates a process of retrograde signaling whereby the depleted stores generate or release a diffusible messenger that is believed to act on the plasma membrane. A phosphorylated metabolite of [Ins(1,4,5)P(3)], inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P(4)], has been proposed to modulate this process, but the literature is not consistent on this point. A recently proposed candidate for the retrograde messenger is an activity extracted from Jurkat cells termed CIF (calcium influx factor), which has many properties consistent with such a messenger. There is also evidence that a GTP-dependent ...Continue Reading

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Citations

Aug 26, 1998·Molecular Reproduction and Development·M N Llanos
Feb 1, 1996·Parasitology Today·R Docampo, S N Moreno
Dec 24, 1997·Clinical and Experimental Pharmacology & Physiology·C van BreemenX Wang
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B VannierL Birnbaumer
Aug 1, 1994·Trends in Endocrinology and Metabolism : TEM·T Balla, K J Catt
Sep 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Pierre-Yves von der WeidDirk F van Helden
Feb 29, 2000·The Journal of Biological Chemistry·D M ZhuP B Chock
Sep 14, 1999·The American Journal of Physiology·A G IglesiasD Becu-Villalobos
Mar 7, 1997·The Journal of Biological Chemistry·R T WaldronD L Gill

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