PMID: 15384203Sep 24, 2004Paper

Calcium mobilization is required for peroxynitrite-mediated enhancement of spontaneous transient outward currents in arteriolar smooth muscle cells

Free Radical Biology & Medicine
Bing-Xing PanKe-Seng Zhao

Abstract

Transiently local release of Ca(2+) from the sarcoplasmic reticulum (SR) activates nearby Ca(2+)-activated K(+) channels to produce spontaneous transient outward currents (STOCs) in smooth muscle cells. The purpose of the present study was to investigate the possible effect of peroxynitrite (ONOO(-)) on STOCs in mesenteric arteriolar smooth muscle cells (ASMCs) and decide whether Ca(2+) mobilization was involved in STOCs alteration by ONOO(-). STOCs were recorded and characterized using the perforated whole-cell patch-clamp configuration. The results demonstrated that STOCs activity was greatly suppressed by removal of extracellular Ca(2+); by addition of nifedipine, a specific inhibitor of L-type voltage-gated Ca(2+) channels (VGCCs); or by addition of ryanodine, a SR ryanodine receptors (RyRs) blocker. In contrast, both caffeine, a RyR activator, and 2-aminoethoxydiphenylborate (2-APB), a membrane-permeable inositol 1,4,5-trisphosphate receptors, (IP3R) antagonist, increased STOCs activity. 3-morpholinosydnonimine (SIN-1), an ONOO(-) donor, at concentrations of 20-200 microM, induced a dose-dependent enhancement of STOCs in ASMCs and led to conspicuous increases in STOCs frequency and amplitude, which were prevented by prior ...Continue Reading

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Feb 1, 1994·Free Radical Biology & Medicine·N W KooyJ S Beckman
Jan 1, 1996·Free Radical Research·R I VinerC Schöneich
Mar 1, 1997·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·W F JacksonN J Rusch
Apr 29, 1998·Pharmacology & Toxicology·A T DemiryürekI Kanzik
Jun 5, 1998·The American Journal of Physiology·J H JaggarM T Nelson
Feb 9, 2000·American Journal of Physiology. Cell Physiology·I D KongK M Sanders
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D C HooperS V Spitsin
Dec 20, 2000·The Journal of Experimental Medicine·B van der LooT F Lüscher
Feb 15, 2001·American Journal of Physiology. Cell Physiology·G M HerreraM T Nelson
Feb 22, 2001·Free Radical Biology & Medicine·R RadiA Cayota
Feb 24, 2001·Journal of Neurochemistry·S OhkumaT Ohgi
Aug 15, 2001·American Journal of Physiology. Cell Physiology·J L KneplerC M Hart
Dec 1, 2001·Free Radical Biology & Medicine·M WeberG Kojda
Nov 7, 2002·Free Radical Biology & Medicine·Sergei V SpitsinD Craig Hooper
Nov 15, 2002·American Journal of Physiology. Cell Physiology·Mandeep WaliaAshok K Grover
Jan 17, 2003·American Journal of Physiology. Cell Physiology·Ashok K GroverChiu Yin Kwan
Mar 7, 2003·American Journal of Physiology. Cell Physiology·Carl White, J Graham McGeown
Mar 15, 2003·American Journal of Physiology. Cell Physiology·Ricardo BullOsvaldo Alvarez
May 28, 2003·Cell Calcium·Mandeep WaliaAshok K Grover
Jun 21, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Warren H LeeMichael S Wolin
Sep 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Mary Lynn BajtHartmut Jaeschke
Mar 24, 2004·Redox Report : Communications in Free Radical Research·Bing-Xing PanKe-Seng Zhao

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Citations

May 11, 2011·Clinical and Experimental Pharmacology & Physiology·Hiromi JoToshiji Iwasaka
May 21, 2011·Journal of Applied Toxicology : JAT·Rui SongKe-seng Zhao
Sep 6, 2005·Nitric Oxide : Biology and Chemistry·Fumiyuki Yamakura, Keiichi Ikeda
Oct 14, 2010·American Journal of Hypertension·Rui SongKe-Seng Zhao
Apr 4, 2017·Journal of Vascular Research·Marie-Ann EwartSimon Kennedy
Dec 13, 2017·ASN Neuro·Kareem ClarkJeffrey L Dupree

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