Abstract
In a transgenic strain of Caenorhabditis elegans carrying a stress-inducible lacZ reporter gene, short-term sublethal exposure to heavy metals activates transgene expression. The transgene response to Cd2+ is strongly inhibited by Ca2+ ions; furthermore, Ca2+ reduces the net accumulation of Cd2+ by worms. Both Ca2+ and a variety of calcium uptake inhibitors (nifedipine, La3+, verapamil) depress the dose response of the transgene to Cd2+. Calcium ionophore (A23187) slightly increases transgene activity in control and Cd2+ treated worms, but has a much larger effect in the case of Mn2+, reflecting its much greater affinity for this ion.
References
Apr 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T S Gill, A Epple
Jul 1, 1992·Genes & Development·K AbravayaR I Morimoto
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A Viarengo, P Nicotera
Oct 31, 1991·Nature·J T WestwoodC Wu
May 3, 1991·Cell·P K Sorger
Oct 1, 1989·Ecotoxicology and Environmental Safety·W H van KesselW Seinen
Dec 1, 1988·Toxicology and Industrial Health·P L Williams, D B Dusenbery
May 1, 1985·Analytical Biochemistry·C M DeberS Grinstein
Jul 1, 1983·Journal of Cellular Physiology·A M Mastro, M C Smith
Jun 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·T P Snutch, D L Baillie
Jan 1, 1993·Annual Review of Genetics·D A Parsell, S Lindquist
Apr 1, 1993·Cell Biology and Toxicology·M FischbachP Bromley
Jul 16, 1993·Cell·J Lis, C Wu
Jan 28, 1993·Nature·J JungmannS Jentsch
Jun 21, 1991·Science·C Mlot
Citations
Dec 14, 2006·Archives of Environmental Contamination and Toxicology·S M WuM J Shih
Sep 6, 2005·Cell Biology and Toxicology·K GuvenD De Pomerai
Sep 26, 2002·Aquatic Toxicology·K Wah Chu, King L Chow
Nov 25, 2000·Toxicology·J G Bierkens
Jun 24, 2008·Journal of Toxicology and Environmental Health. Part a·P S RajiniPhillip L Williams
Nov 1, 2011·Ecotoxicology·Charumathi AnbalaganDavid de Pomerai
Oct 20, 2012·Ecotoxicology·Charumathi AnbalaganDavid I De Pomerai
Apr 19, 2006·Ecotoxicology and Environmental Safety·Hiroaki HaradaToshihiko Eki
Jan 22, 2008·Environmental Pollution·Chafik MaazouziJean-Claude Pihan
Dec 22, 2005·Immunology Letters·E L CooperP Nemeth
Apr 1, 1996·Human & Experimental Toxicology·D de Pomerai