PMID: 7538410Jan 1, 1995Paper

Calcium moderation of cadmium stress explored using a stress-inducible transgenic strain of Caenorhabditis elegans

Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
K GuvenD de Pomerai

Abstract

In a transgenic strain of Caenorhabditis elegans carrying a stress-inducible lacZ reporter gene, short-term sublethal exposure to heavy metals activates transgene expression. The transgene response to Cd2+ is strongly inhibited by Ca2+ ions; furthermore, Ca2+ reduces the net accumulation of Cd2+ by worms. Both Ca2+ and a variety of calcium uptake inhibitors (nifedipine, La3+, verapamil) depress the dose response of the transgene to Cd2+. Calcium ionophore (A23187) slightly increases transgene activity in control and Cd2+ treated worms, but has a much larger effect in the case of Mn2+, reflecting its much greater affinity for this ion.

References

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Citations

Dec 14, 2006·Archives of Environmental Contamination and Toxicology·S M WuM J Shih
Sep 6, 2005·Cell Biology and Toxicology·K GuvenD De Pomerai
Jun 24, 2008·Journal of Toxicology and Environmental Health. Part a·P S RajiniPhillip L Williams
Nov 1, 2011·Ecotoxicology·Charumathi AnbalaganDavid de Pomerai
Apr 19, 2006·Ecotoxicology and Environmental Safety·Hiroaki HaradaToshihiko Eki
Dec 22, 2005·Immunology Letters·E L CooperP Nemeth
Apr 1, 1996·Human & Experimental Toxicology·D de Pomerai

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