Calcium Oscillation Frequency-Sensitive Gene Regulation and Homeostatic Compensation in Pancreatic β-Cells

Bulletin of Mathematical Biology
Vehpi Yildirim, R Bertram

Abstract

Pancreatic islet [Formula: see text]-cells are electrically excitable cells that secrete insulin in an oscillatory fashion when the blood glucose concentration is at a stimulatory level. Insulin oscillations are the result of cytosolic [Formula: see text] oscillations that accompany bursting electrical activity of [Formula: see text]-cells and are physiologically important. ATP-sensitive [Formula: see text] channels (K(ATP) channels) play the key role in setting the overall activity of the cell and in driving bursting, by coupling cell metabolism to the membrane potential. In humans, when there is a defect in K(ATP) channel function, [Formula: see text]-cells fail to respond appropriately to changes in the blood glucose level, and electrical and [Formula: see text] oscillations are lost. However, mice compensate for K(ATP) channel defects in islet [Formula: see text]-cells by employing alternative mechanisms to maintain electrical and [Formula: see text] oscillations. In a recent study, we showed that in mice islets in which K(ATP) channels are genetically knocked out another [Formula: see text] current, provided by inward-rectifying [Formula: see text] channels, is increased. With mathematical modeling, we demonstrated that a ...Continue Reading

References

Jan 1, 1979·Annual Review of Biochemistry·C Frieden
May 1, 1991·Pflügers Archiv : European journal of physiology·R M SantosM Valdeolmillos
Mar 1, 1991·The Journal of Clinical Endocrinology and Metabolism·G PaolissoP J Lefèbvre
May 12, 1988·The New England Journal of Medicine·S O'RahillyD R Matthews
May 12, 1988·The New England Journal of Medicine·K S PolonskyE Van Cauter
Apr 1, 1983·Diabetologia·D R MatthewsR C Turner
Aug 11, 1995·Cell·G HajnóczkyA P Thomas
Jan 1, 1995·Advances in Second Messenger and Phosphoprotein Research·L B RosenM E Greenberg
May 1, 1995·Bulletin of Mathematical Biology·R BertramA Sherman
Mar 26, 1993·Science·G LeMassonL F Abbott
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·O LarssonP O Berggren
Jan 1, 1997·Annual Review of Immunology·A RaoP G Hogan
Jan 31, 1998·Science·P De Koninck, H Schulman
Sep 2, 1998·The EMBO Journal·L D Robb-GaspersA P Thomas
Mar 29, 2000·The Journal of Biological Chemistry·V SeghersJ Bryan
May 9, 2000·Biochemical and Biophysical Research Communications·T IwakuraY Seino
Jan 3, 2001·The Journal of Clinical Endocrinology and Metabolism·S H SongP C Butler
May 3, 2001·The Journal of Biological Chemistry·T J CollinsM D Bootman
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·A E WestM E Greenberg
Nov 9, 2001·Journal of Cardiovascular Electrophysiology·E J VigmondR A Malkin
Feb 15, 2002·Diabetologia·N Pørksen
Jan 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jun ZhouGideon Koren
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Michael J BerridgeH Llewelyn Roderick
Aug 6, 2003·The Journal of Biological Chemistry·Man XuNorbert Klugbauer
Aug 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·J Michael BradshawHoward Schulman
Oct 24, 2003·Cell Calcium·Geneviève DupontPaul De Koninck
Apr 17, 2004·Circulation Research·Barbara Rosati, David McKinnon
Aug 6, 2004·Bulletin of Mathematical Biology·Richard Bertram, Arthur Sherman
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Kathrin MaedlerMarc Y Donath
Jun 17, 2006·Annual Review of Neuroscience·Graeme W Davis
Oct 9, 2007·Biophysical Journal·Carlos SalazarThomas Höfer
Oct 25, 2007·FEMS Microbiology Letters·Daniel Yuen-Teh LiuTzong-Hsiung Hseu
May 9, 2008·Cellular and Molecular Life Sciences : CMLS·M T Swulius, M N Waxham

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Citations

Feb 19, 2020·American Journal of Physiology. Endocrinology and Metabolism·Nathan C LawCraig S Nunemaker
Oct 1, 2020·Scientific Reports·Srinivas Gorur-ShandilyaTimothy O'Leary

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