PMID: 38126Jul 1, 1979

Calcium overload and mechanical function in posthypoxic myocardium: biphasic effect of pH during hypoxia

European Journal of Cardiology
E G LakattaP A Poole-Wilson


Mechanical function and calcium accumulation in the myocardium during and after hypoxia were examined in the isolated but arterially perfused interventricular rabbit septum. The pH of the perfusate during hypoxia was varied from 7.4 to 6.6 by increase of the pCO2. All septa were reoxygenated for 30 min at pH 7.4. In the posthypoxic period the recovery of developed tension was greatest and the magnitude of contracture least in those septa perfused at pH 6.8 during hypoxia; calcium overload did not occur. By contrast, marked calcium overload (3.5 mumol/g wet wt) occurred in septa perfused at pH 7.4 during hypoxia. Reduction of pH to 6.6 during hypoxia did not result in a greater degree of recovery of developed tension or complete reversal of contracture in the posthypoxic period, and marked calcium overload was not prevented. These results indicate that: (1) partial recovery of mechanical function in the posthypoxic period can occur concurrent with a net gain of calcium; (2) the beneficial effects on recovery in the posthypoxic period in septa perfused at pH 6.8 during hypoxia may be in part released to prevention of calcium overload; (3) the beneficial effects of acidosis are lost when the perfusate pH is reduced to 6.6 during h...Continue Reading

Related Concepts

Myocardial Contraction
Calcium [EPC]
Cell Septum
Tension Headache
Anion Gap

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.