PMID: 8583571Mar 1, 1996Paper

Calcium oxalate-crystal membrane interactions: dependence on membrane lipid composition

The Journal of Urology
M W BigelowN S Mandel

Abstract

Urolithiasis is clearly a multifaceted process, progressing from urine supersaturation to the formation of mature renal calculi. Retention of microcrystals by the urothelium is a critical event in stone maturation. Membrane phospholipids appear to be involved in the attachment of stone crystals to kidney epithelium. The current study quantitates crystal-membrane interactions following selective changes in the red blood cell (RBC) membrane phospholipid composition by using a crystal-induced membranolytic assay. Membrane enrichment with anionic phospholipids was found to greatly increase crystal-membrane interactions. Crystal-membrane interaction was associated with an increase in the negative charge on the RBC membrane surface. Specific membrane compositions seem to facilitate the formation of crystal attachment region on the RBC surface that is necessary for effective crystal attachment to the cell membrane.

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Citations

Jan 1, 1997·World Journal of Urology·C F VerkoelenJ C Romijn
Jul 6, 2004·Urological Research·Katsuhito MiyazawaShogo Katsuda
Aug 5, 2000·Current Opinion in Nephrology and Hypertension·J C Lieske, F G Toback
Oct 24, 2013·BioMed Research International·Kanu Priya AggarwalChanderdeep Tandon
Mar 30, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·John W M YuenDoris W T Au
Jul 13, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Masao TsujihataAkihiko Okuyama
Mar 3, 2010·Immunological Reviews·Yan ShiGilbert Ng
Jul 6, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shamim MushtaqJawed Shafqat
May 7, 2014·BioMed Research International·Wei-Chih KanWei-Chiao Chang
Aug 20, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro YasuiKenjiro Kohri
Feb 13, 2001·Kidney International·J H WiessnerN S Mandel
Sep 23, 2008·The Journal of Urology·Masao TsujihataAkihiko Okuyama
Jul 25, 2009·The Journal of Urology·Chikahiro MomoharaAkihiko Okuyama
May 19, 2006·Journal of the American Society of Nephrology : JASN·Carl Friedrich Verkoelen
Feb 14, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Masao Tsujihata
Jun 22, 2012·Protein & Cell·Yan Shi

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