Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6

Nature Genetics
Zhirong JiangPeter S Aronson

Abstract

Urolithiasis is one of the most common urologic diseases in industrialized societies. Calcium oxalate is the predominant component in 70-80% of kidney stones, and small changes in urinary oxalate concentration affect the risk of stone formation. SLC26A6 is an anion exchanger expressed on the apical membrane in many epithelial tissues, including kidney and intestine. Among its transport activities, SLC26A6 mediates Cl(-)-oxalate exchange. Here we show that mutant mice lacking Slc26a6 develop a high incidence of calcium oxalate urolithiasis. Slc26a6-null mice have significant hyperoxaluria and elevation in plasma oxalate concentration that is greatly attenuated by dietary oxalate restriction. In vitro flux studies indicated that mice lacking Slc26a6 have a defect in intestinal oxalate secretion resulting in enhanced net absorption of oxalate. We conclude that the anion exchanger SLC26A6 has a major constitutive role in limiting net intestinal absorption of oxalate, thereby preventing hyperoxaluria and calcium oxalate urolithiasis.

References

Dec 1, 1985·The Journal of Urology·P G WernessB Finlayson
Dec 1, 1994·Journal of the American Society of Nephrology : JASN·M HatchN D Vaziri
Jun 28, 1996·The Journal of Biological Chemistry·S M Kuo, P S Aronson
Dec 20, 1996·The Journal of Biological Chemistry·M S WuP S Aronson
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·F KnaufP S Aronson
Feb 14, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zhaohui WangManoocher Soleimani
Jul 18, 2002·The Journal of Biological Chemistry·Zhirong JiangPeter S Aronson
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Qizhi XieDavid B Mount
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Lawrence P KarniskiPeter S Aronson
Dec 12, 2002·Endocrinology and Metabolism Clinics of North America·John R Asplin
Jun 29, 2004·Urological Research·Ross P Holmes, Dean G Assimos
Aug 17, 2004·American Journal of Physiology. Cell Physiology·Sadasivan VidyasagarHenry J Binder
Dec 3, 2004·American Journal of Physiology. Cell Physiology·Zhaohui WangManoocher Soleimani
Feb 3, 2005·American Journal of Physiology. Renal Physiology·Hetal S KocinskyPeter S Aronson
Jun 1, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Niv PalgiBerry Pinshow
Aug 12, 2005·The Journal of Urology·Ross P HolmesDean G Assimos
Dec 24, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert W FreelManoocher Soleimani

❮ Previous
Next ❯

Citations

Jun 12, 2009·Urological Research·Saeed R Khan, Benjamin K Canales
Apr 7, 2010·Histochemistry and Cell Biology·Jeannie M Chapman, Lawrence P Karniski
Apr 4, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Velibor TasicHae Il Cheong
Jun 27, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tadeusz PorowskiHalina Porowska
Jun 22, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Massimo Attanasio
Jun 5, 2008·Nature Clinical Practice. Nephrology·Susan R Marengo, Andrea M P Romani
Aug 1, 2009·The Journal of Biological Chemistry·Min-Hwang ChangMichael F Romero
Feb 2, 2011·The Journal of General Physiology·Ehud OhanaShmuel Muallem
Aug 30, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sharon BaroneManoocher Soleimani
Aug 19, 2007·Current Opinion in Nephrology and Hypertension·Aleksandra SindićMichael F Romero
Sep 28, 2006·Annual Review of Physiology·Daniel Markovich, Peter S Aronson
Mar 12, 2010·American Journal of Physiology. Cell Physiology·John F HeneghanSeth L Alper
Oct 1, 2011·American Journal of Physiology. Cell Physiology·Hatim A HassanPeter S Aronson
May 20, 2011·American Journal of Physiology. Cell Physiology·Andrew K StewartSeth L Alper
Apr 21, 2012·American Journal of Physiology. Cell Physiology·Narae KoPeter S Aronson
May 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert W FreelMarguerite Hatch
Feb 13, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Janet E SimpsonLane L Clarke
Dec 18, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marguerite HatchRobert W Freel
Oct 9, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Akira KatoMichael F Romero
Sep 21, 2012·American Journal of Physiology. Renal Physiology·Taku HirataMichael F Romero
Jul 2, 2010·American Journal of Physiology. Renal Physiology·Yan LiuXue-Ru Wu
Dec 3, 2010·American Journal of Physiology. Renal Physiology·Kristin J BergslandFredric L Coe
Aug 6, 2010·American Journal of Physiology. Renal Physiology·Michael F Romero
Mar 14, 2008·American Journal of Physiology. Renal Physiology·Saeed R Khan, Patricia A Glenton
Feb 3, 2012·Physiological Reviews·Min Goo LeeShmuel Muallem
Nov 30, 2007·American Journal of Nephrology·Snezana PetrovicManoocher Soleimani
Nov 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Alok K SharmaSeth L Alper
Feb 18, 2010·The Journal of Clinical Investigation·Paul A DawsonDaniel Markovich
Apr 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Khashayar SakhaeeBridget Sinnott
Mar 7, 2008·Journal of the American Society of Nephrology : JASN·David W KaufmanDavid R Cave
Oct 25, 2011·Journal of the American Society of Nephrology : JASN·Felix KnaufPeter S Aronson
Apr 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Thorsten J Schaechinger, Dominik Oliver
Nov 19, 2013·Pflügers Archiv : European journal of physiology·Jeong Hee HongShmuel Muallem
Nov 9, 2010·Annual Review of Physiology·Akira Kato, Michael F Romero
Jan 10, 2012·Clinical Reviews in Bone and Mineral Metabolism·Vishal N Ratkalkar, Jack G Kleinman
Aug 24, 2013·The American Journal of Medicine·Yeong-Hau H Lien
Mar 20, 2013·Molecular Aspects of Medicine·Seth L Alper, Alok K Sharma
Jul 30, 2011·Kidney International·Felix Knauf, Patricia A Preisig
May 3, 2013·Kidney International·Manoocher Soleimani
May 23, 2008·Kidney International·Anurag Kumar SinghManoocher Soleimani
Dec 17, 2008·Kidney International·Khashayar Sakhaee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved