Calcium phosphate composite layers for surface-mediated gene transfer

Acta Biomaterialia
Ayako OyaneHideo Tsurushima

Abstract

In this review, the surface-mediated gene transfer system using calcium phosphate composite layers is described. Calcium phosphate ceramics are osteoconductive bioceramics used typically in orthopedic and dental applications. Additionally, calcium phosphate particles precipitated by a liquid-phase process have long been used as a safe and biocompatible transfection reagent in molecular biology. Recently, calcium phosphate composite layers immobilizing DNA were fabricated on the surfaces of base materials through a biomimetic process using supersaturated solutions. These composite layers possess useful characteristics of both osteoconductive bioceramics and transfection reagents; they thus provide a biocompatible surface to support cell adhesion and growth, and can stimulate the cell effectively via surface-mediated gene transfer. By modifying the fabrication conditions, physicochemical and biological properties of the composite layers can be varied. With such an approach, these composite layers can be designed to have improved affinity for cells and to exhibit increased gene transfer efficiency over that of conventional lipid transfection reagents. The composite layers with the increased gene transfer efficiency induced specifi...Continue Reading

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Citations

Mar 1, 2012·Journal of Materials Science. Materials in Medicine·Ayako OyaneHideo Tsurushima
Sep 21, 2013·International Journal of Molecular Sciences·Hirotaka MutsuzakiAyako Oyane
Dec 20, 2013·International Journal of Molecular Sciences·Hirotaka MutsuzakiAtsuo Ito
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Wen-Cheng ChenChien-Lin Huang
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Bing LiuYu-peng Lu
Aug 12, 2015·Journal of Functional Biomaterials·Sergey V Dorozhkin
Apr 16, 2015·International Journal of Molecular Sciences·Yushin YazakiHideo Tsurushima
Jun 29, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Sergey V Dorozhkin
Jun 26, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Govinda BhattaraiHo-Keun Yi
Jan 10, 2018·Journal of Biomedical Materials Research. Part a·Ryosuke IwamaOsamu Suzuki
Jan 27, 2019·Journal of Biomedical Materials Research. Part a·Yukari ShiwakuOsamu Suzuki
Nov 8, 2012·Science and Technology of Advanced Materials·Yushin YazakiHideo Tsurushima
Oct 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Maki Nakamura, Ayako Oyane
May 15, 2013·Science and Technology of Advanced Materials·Xiupeng WangJiandong Ye
Mar 16, 2021·ACS Biomaterials Science & Engineering·Yu ZhuangHongbo Yu
Sep 25, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Ayako OyaneHirofumi Miyaji
Jul 10, 2017·ACS Biomaterials Science & Engineering·Ana CivantosAnder Abarrategi

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