PMID: 10753216Apr 7, 2000Paper

Calcium phosphate-containing precipitate and the carcinogenicity of sodium salts in rats

Carcinogenesis
S M CohenR A Shaw

Abstract

Sodium saccharin, ascorbate and other sodium salts fed at high doses to rats produce urinary bladder urothelial cytotoxicity with consequent regenerative hyperplasia. For sodium salts that have been tested, tumor activity is enhanced when administered either alone or after a brief exposure to a known genotoxic bladder carcinogen. These sodium salts alter urinary composition of rats resulting in formation of an amorphous precipitate. We examined the precipitate to ascertain its composition and further delineate the basis for its formation in rat urine. Using scanning electron microscopy with attached X-ray energy dispersive spectroscopy, the principal elements present were calcium, phosphorus, minor amounts of silicon and sulfur. Smaller elements are not detectable by this method. Infrared analyses demonstrated that calcium phosphate was in the tribasic form and silicon was most likely in the form of silica. Small amounts of saccharin were present in the precipitate from rats fed sodium saccharin (<5%), but ascorbate was not detectable in the precipitate from rats fed similar doses of sodium ascorbate. Large amounts of urea and mucopolysaccharide, apparently chondroitin sulfate, were detected in the precipitate by infrared analy...Continue Reading

References

Apr 1, 1979·British Journal of Cancer·J Chowaniec, R M Hicks
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M WiglerL Chasin
Jul 1, 1979·Mutation Research·C W Moore, A Schmick
Nov 1, 1977·Chemico-biological Interactions·W K Lutz, C Schlatter
Apr 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·T OkamuraS M Cohen
Oct 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E M GarlandS M Cohen
Jan 1, 1990·Critical Reviews in Toxicology·L B Ellwein, S M Cohen
Jan 1, 1989·Experimental Pathology·N Ito, S Fukushima
Sep 1, 1989·Mutation Research·D L Arnold, B G Boyes
Jan 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M J FisherS M Cohen
Feb 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·C B FrederickF F Kadlubar
May 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A P de GrootH R Immel
Jun 10, 1988·Journal of Chromatography·T S TibbelsS M Cohen
Mar 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D S WilliamsonS M Cohen
Mar 1, 1986·Cancer Letters·R Hasegawa, S M Cohen
Oct 1, 1986·Toxicology and Applied Pharmacology·S L JohanssonS M Cohen
Apr 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G P SchoenigF W Carlborg
Jul 1, 1983·Toxicology·D L ArnoldI C Munro
Feb 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S FukushimaN Ito
Jan 1, 1980·Toxicology and Applied Pharmacology·D L ArnoldI C Munro
Sep 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S M Cohen
Sep 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G C Hard
Sep 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D B ClaysonS M Cohen
Feb 1, 1995·Carcinogenesis·S M CohenL L Arnold
Nov 1, 1994·Carcinogenesis·S M CohenD L van Goethem
Feb 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S ShioyaS Fukushima
Mar 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R W WestF F Kadlubar
Oct 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E M GarlandS M Cohen
Mar 1, 1996·Toxicologic Pathology·S M CohenE M Garland
May 6, 1999·The New England Journal of Medicine·D S MichaudE L Giovannucci
Jan 2, 2009·Cancer Research·Ezra E W CohenMarsha Rich Rosner

❮ Previous
Next ❯

Citations

Mar 26, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Virunya S BhatClifton J McLellan
Dec 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samuel M Cohen, Lora L Arnold
Mar 6, 2012·Urologic Oncology·Kyle J KirilukNorm D Smith
May 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Masanao YokohiraKatsumi Imaida
May 23, 2008·Preventive Medicine·M M AndreattaA Navarro
Jul 28, 2005·Toxicology and Applied Pharmacology·Lunbiao CuiXinru Wang
Jun 27, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiao-Li XieHideki Wanibuchi
Nov 5, 2011·Critical Reviews in Toxicology·Gwendolyn L BallVirunya S Bhat
Nov 30, 2013·Regulatory Toxicology and Pharmacology : RTP·Palma Ann MaroneA Wallace Hayes
Sep 1, 2011·International Journal of Toxicology·Susan van TongerenLyn M Wancket
Jul 29, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samuel M Cohen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
S M Cohen
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D B ClaysonS M Cohen
© 2021 Meta ULC. All rights reserved