Calcium Phosphate Nanoparticles as Intrinsic Inorganic Antimicrobials: The Antibacterial Effect

ACS Applied Materials & Interfaces
Victoria M WuVuk Uskoković

Abstract

Cheap and simple to make, calcium phosphate (CP), thanks to its unusual functional pleiotropy, belongs to the new wave of abundant and naturally accessible nanomaterials applicable as a means to various technological ends. It is used in a number of industries, including the biomedical, but its intrinsic antibacterial activity in the nanoparticle form has not been sufficiently explored to date. In this study, we report on this intrinsic antibacterial effect exhibited by two distinct CP phases: an amorphous CP (ACP) and hydroxyapatite (HAp). The effect is prominent against a number of regular bacterial species, including Staphylococcus aureus, Staphylococcus epidermis, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa, but also their multidrug-resistant (MDR) analogues. Although ACP and HAp displayed similar levels of activity against Gram-negative organisms, ACP proved to be more effective against the Gram-positive ones, with respect to which HAp was mostly inert, yet this trend became reversed for the MDR strains. In addition to the intrinsic antimicrobial effect of CP nanoparticles, we have also observed a synergistic effect between the nanoparticles and certain antibiotics. Both forms of CP were engaged in a...Continue Reading

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Citations

Jun 2, 2020·Drug Development and Industrial Pharmacy·Behrad GhiasiVuk Uskoković
Jan 16, 2020·Foundations of Science·Victoria Wu, Vuk Uskoković
Jul 4, 2020·Biomedical Materials·Victoria M WuVuk Uskoković
Apr 24, 2021·Chemistry : a European Journal·Paula BorovikMatías Jobbágy
Aug 17, 2021·Journal of Colloid and Interface Science·Rita GelliPiero Baglioni
Dec 9, 2019·ACS Biomaterials Science & Engineering·Julietta V RauVuk Uskoković

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