Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint - FNA findings and microanalysis.

CytoJournal
Asghar H NaqviKamal K Khurana

Abstract

We report a case of a Calcium pyrophosphate dihydrate deposition disease (CPPD) presenting as a mass in the parotid and temporomandibular joint (TMJ) that simulated a parotid tumor. A 35 year-old man presented with pain in the left ear area. A CT Scan of the area showed a large, calcified mass surrounding the left condylar head, and extending into the infratemporal fossa. FNA of the mass showed birefringent crystals, most of which were rhomboid with occasional ones being needle shaped, embedded in an amorphous pink substance. Scanning electron microscopy (SEM) with energy dispersive x-ray spectroscopy (EDS) of these crystals showed peaks corresponding to calcium and phosphorus. SEM/EDS is a rapid method of diagnosing calcium pyrophosphate dihydrate deposition disease (CPPD) and an alternative to more commonly used method of special staining of cell block sections coupled with polarizing microscopy.

References

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Citations

Mar 5, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·G CacciottiD Fiume
Jan 27, 2012·CytoJournal·Vinod B ShidhamMartha B Pitman
Oct 1, 2011·Journal of the American Podiatric Medical Association·Matthias A ErhardtChristian B Frank
Aug 23, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Daniel ZweifelJoachim Obwegeser
Apr 12, 2018·Diagnostic Cytopathology·Hema SubramanianNeelaiah Siddaraju
Oct 1, 2016·JBJS Case Connector·Ryan KrochakHoward Goodman
Sep 13, 2018·Maxillofacial Plastic and Reconstructive Surgery·Kwang-Jun KwonHang-Moon Choi

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Methods Mentioned

BETA
light microscopy
polarizing microscopy
transmission electron microscopy
infrared
Scanning Electron Microscopy

Software Mentioned

Diff

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