PMID: 2507738Aug 1, 1989Paper

Calcium regulates some, but not all, aspects of light adaptation in rod photoreceptors

The Journal of General Physiology
G D Nicol, M D Bownds

Abstract

The role of calcium as a regulator of light adaptation in rod photoreceptors was examined by manipulation of the intracellular Ca2+ concentration through the use of the calcium ionophore A23187 and external Ca2+ buffers. These studies utilized suspensions of isolated and purified frog rod outer segments that retain their mitochondria-rich inner segments (OS-IS). Three criteria of the dark- and light-adapted flash response were characterized as a function of the Ca2+ concentration: (a) the time to peak, (b) the rate of recovery, and (c) the response amplitude or sensitivity. For all Ca2+ concentrations examined, the time to peak of the flash response was accelerated in the presence of background illumination, suggesting that mechanisms controlling this aspect of adaptation are independent of the Ca2+ concentration. The recovery kinetics of the flash response appeared to depend on the Ca2+ concentration. In 1 mM Ca2+-Ringer's and 300 nM Ca2+-Ringer's + A23187, background illumination enhanced the recovery rate of the response; however, in 10 and 100 nM Ca2+-Ringer's + A23187, the recovery rates were the same for dark- and light-adapted responses. This result implies that a critical level of Ca2+ may be necessary for background il...Continue Reading

Citations

Jan 1, 1989·Progress in Biophysics and Molecular Biology·P P Schnetkamp
Sep 1, 1990·Trends in Neurosciences·G L Fain, H R Matthews
Aug 1, 1991·Current Opinion in Neurobiology·K W Yau
Oct 1, 1991·Visual Neuroscience·S M Dawis
Jan 1, 1994·Visual Neuroscience·D R PepperbergG J Jones
Mar 1, 1997·The Journal of General Physiology·M P Gomez, E Nasi
Jan 1, 1992·Scandinavian Journal of Psychology·U StabellA Fugelli
Oct 1, 1995·Cell Calcium·K W Koch
Apr 22, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Katerina DamianakiMenno Pruijm
Jan 1, 1992·Visual Neuroscience·D R PepperbergH Ripps
Jan 12, 2001·Physiological Reviews·G L FainY Koutalos
Aug 1, 1992·Trends in Biochemical Sciences·K W Koch

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