Calcium responsiveness in regional myocardial short-term hibernation and stunning in the in situ porcine heart. Inotropic responses to postextrasystolic potentiation and intracoronary calcium

Circulation
G HeuschR Schulz

Abstract

We tested the hypothesis that decreased calcium responsiveness is responsible for the reduction in contractile function in regional hibernating and stunned myocardium in situ. In 19 anesthetized swine, the left anterior descending coronary artery flow was reduced to decrease anterior myocardial work index (sonomicrometry) by approximately 60%. During 90 minutes of hypoperfusion, creatine phosphate recovered (as determined by biopsy specimens and bioluminescence) and no necrosis developed (as determined by staining with triphenyl tetrazolium chloride). In 10 swine, changes in the intracellular calcium concentration were induced by systematic variation of the postextrasystolic time interval at a constant prematurity. In 9 additional swine, a graded IC calcium infusion was performed. Under control conditions, anterior myocardial work increased with a fully compensated postextrasystolic time interval from 380+/-93 (mean+/-SD) to 523+/-98 mm Hg . mm. IC calcium infusion increased anterior myocardial work under control conditions from 356+/-85 to a maximum of 428+/-93 mm Hg . mm. Although the maximal responses were decreased during postextrasystolic potentiation (222+/-68 versus 523+/-98 mm Hg . mm) and calcium infusion (176+/-32 ver...Continue Reading

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Citations

Jun 26, 2008·Basic Research in Cardiology·Andreas SkyschallyGerd Heusch
Jan 13, 2012·Basic Research in Cardiology·Dániel CzurigaZoltán Papp
Jun 15, 2012·Wiener medizinische Wochenschrift·Petra KleinbongardGerd Heusch
Aug 4, 1997·The American Journal of Cardiology·G Heusch, R Schulz
Aug 10, 1999·Journal of the American College of Cardiology·Y ChandrashekharI S Anand
Jun 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·H SchadN Mendler
Jun 29, 2001·Trends in Cardiovascular Medicine·G Heusch, R Schulz
Jun 27, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·C ChenD Waters
Jul 17, 1998·The New England Journal of Medicine·W WijnsP G Camici
Jan 22, 2005·Echocardiography·Holger P Salazar, James V Talano
Jan 18, 2006·Acta Pharmacologica Sinica·Zuo-lin FuXiang Gu
Nov 18, 2000·Heart·R Schulz, G Heusch
Feb 8, 2008·Molecular Medicine·Michael A FlierlPeter A Ward
Oct 3, 2000·Journal of Molecular and Cellular Cardiology·H LüssG Heusch
Mar 9, 2011·Journal of Molecular and Cellular Cardiology·Gerd HeuschRainer Schulz
Apr 10, 2009·JACC. Cardiovascular Imaging·Shahbudin H RahimtoolaJean-Louis J Vanoverschelde
Mar 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Juan Gabriel BarraRicardo Horacio Pichel
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Gerd HeuschShahbudin H Rahimtoola
Feb 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Marcella CantonFabio Di Lisa
Oct 28, 1998·Physiological Reviews·G Heusch
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H LüssW Schmitz
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T Stumpe, J Schrader
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R SchulzG Heusch
Mar 8, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Claus MartinGerd Heusch
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·E R SchwarzP Hanrath
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R K KudejS F Vatner
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R SchulzG Heusch
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H KöglerE Marbán
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H PostG Heusch
Sep 25, 1998·Cardiovascular Research·D J DunckerP D Verdouw
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R SchulzG Heusch
Dec 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Johanna JansenRainer Schulz
Apr 30, 1999·Physiological Reviews·R Bolli, E Marbán
Jul 31, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Kristoffer RussellOtto A Smiseth
Sep 2, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Andrew E Arai
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R SchulzG Heusch
Feb 4, 2021·Nature Reviews. Cardiology·Gerd Heusch
Aug 3, 2010·The Journal of Experimental Biology·Ulrich FlögelTienush Rassaf

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