PMID: 9174241May 20, 1997Paper

Calcium-sensing receptor in the rat hippocampus: a developmental study

Brain Research. Developmental Brain Research
N ChattopadhyayR M Lechan

Abstract

The extracellular Ca2+ (Ca2+(o))-sensing receptor (CaR) plays a key role in maintaining near constancy of Ca2+(o) in mammals through its presence in parathyroid gland and kidney. The CaR is also present in brain, and although its role(s) in the brain is not known, it is possible that small changes in Ca2+(o) modify essential physiological and pathological processes, since calcium is crucial for numerous neuronal functions. Northern analysis has revealed that the CaR mRNA is present in hippocampus and several other regions of the brain. The hippocampus is an important site for learning and memory, but the relevance of the CaR to these processes is unknown. Long-term potentiation (LTP), a putative in vitro analog of memory, can only be induced after 7-10 days postnatally in rat hippocampus. Therefore, in the present study we determined the time course for the developmental expression of the CaR in rat hippocampus to assess its relationship to the development of other important hippocampal functions, such as the capacity for induction of LTP. Northern and Western analyses showed that CaR mRNA and protein were expressed at low levels at 5 days postnatally but then increased markedly at 10 days. A high level of receptor expression, ...Continue Reading

References

Jan 2, 1987·Science·R J Miller
Sep 1, 1989·The Journal of Cell Biology·K L Lankford, P C Letourneau
Jan 1, 1989·Annals of the New York Academy of Sciences·S B KaterP B Guthrie
Jun 1, 1995·Current Opinion in Neurobiology·W J Gallin, M E Greenberg
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·M RuatS H Snyder
May 26, 1995·The Journal of Biological Chemistry·J E GarrettF Fuller
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·D RiccardiS C Hebert
Mar 1, 1994·Journal of Neurobiology·A GhoshM E Greenberg
Apr 15, 1993·Nature
Dec 1, 1995·Cell·E M BrownS C Hebert

❮ Previous
Next ❯

Citations

Oct 8, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Minxuan SunJochen Graw
Jul 17, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Martial Ruat, Elisabeth Traiffort
Jul 17, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Gerda E Breitwieser
Jun 18, 2004·Cell Calcium·Shozo YanoNaibedya Chattopadhyay
Aug 30, 2005·Comptes rendus biologies·Tristan Bouschet, Jeremy M Henley
Oct 26, 2000·Trends in Pharmacological Sciences·A D ConigraveE M Brown
Aug 15, 2000·The International Journal of Biochemistry & Cell Biology·N Chattopadhyay
Jan 29, 2008·Nature Neuroscience·Thomas N VizardAlun M Davies
Apr 28, 2010·The Journal of Biological Chemistry·Alice CavanaughGerda E Breitwieser
Aug 28, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ann StepanchickGerda E Breitwieser
Jan 8, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M G HouseE M Brown
Nov 7, 2006·Trends in Endocrinology and Metabolism : TEM·Arthur D Conigrave, David R Hampson
Mar 26, 2010·Journal of Neuroscience Research·Sanghamitra BandyopadhyayNaibedya Chattopadhyay
Nov 23, 2013·Journal of Cellular Physiology·Hila AsrafMichal Hershfinkel
Apr 3, 2003·The Journal of Clinical Investigation·Claudine H KosMartin R Pollak
Dec 3, 2014·Progress in Neurobiology·Froylan Vargas-MartínezIsmael Jiménez-Estrada
Jun 1, 2016·Frontiers in Physiology·Silvia Mateo-LozanoCarmen de Torres
Jun 16, 2016·Frontiers in Physiology·Sujeenthar Tharmalingam, David R Hampson
Apr 7, 2010·Biochemical and Biophysical Research Communications·Ann Stepanchick, Gerda E Breitwieser
Feb 28, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jonathan E Cohen, R Douglas Fields
Feb 25, 2009·Endocrine Reviews·Zuzana SaidakEdward M Brown
Sep 28, 2006·American Journal of Physiology. Endocrinology and Metabolism·Naibedya ChattopadhyayEdward M Brown
Aug 8, 2001·The Journal of Biological Chemistry·L GamaG E Breitwieser
Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·S U GoebelJ Serrano
Aug 24, 2010·Endocrine Reviews·Aaron L MagnoThomas Ratajczak
Feb 12, 1998·The American Journal of Physiology·N ChattopadhyayE M Brown
Nov 17, 2017·Journal of Neurophysiology·Walter E Babiec, Thomas J O'Dell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.