Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon

American Journal of Physiology. Gastrointestinal and Liver Physiology
Lieqi TangSam X Cheng

Abstract

Colonic bicarbonate (HCO3(-)) secretion is a well-established physiological process that is closely linked to overall fluid and electrolyte movement in the mammalian colon. These present studies show that extracellular calcium-sensing receptor (CaSR), a fundamental mechanism for sensing and regulating ionic and nutrient compositions of extracellular milieu in the small and large intestine, regulates HCO3(-) secretion. Basal and induced HCO3(-) secretory responses to CaSR agonists were determined by pH stat techniques used in conjunction with short-circuit current measurements in mucosa from rat distal colon mounted in Ussing chambers. R568, a specific CaSR activator, stimulated lumen Cl(-)- and short-chain fatty acid (SCFA)-dependent HCO3(-) secretion but inhibited cyclic nucleotide-activated HCO3(-) secretion. Consequently, at physiological conditions (either at basal or during lumen acid challenge) when electroneutral Cl(-)/HCO3(-) and SCFA/HCO3(-) exchangers dominate, CaSR stimulates HCO3(-) secretion; in contrast, in experimental conditions that stimulate fluid and HCO3(-) secretion, e.g., when forskolin activates electrogenic cystic fibrosis transmembrane conductance regulator-mediated HCO3(-) conductance, CaSR activation ...Continue Reading

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M FieldP L Smith
Aug 1, 1975·The Journal of Clinical Investigation·C HolmbergK Launiala
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M G CurrieC E Smith
Feb 12, 1987·The New England Journal of Medicine·J I IsenbergM A Koss
Dec 17, 1982·Science·M J WelshR A Frizzell
Sep 1, 1983·The American Journal of Physiology·M Haas, T J McManus
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·D RiccardiS C Hebert
Nov 14, 1997·The American Journal of Physiology·L GamaG E Breitwieser
Apr 18, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Y SheininH S Cross
Jan 12, 2001·Physiological Reviews·E M Brown, R J MacLeod
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sam X ChengSteven C Hebert
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·J NearingH W Harris
Aug 2, 2003·Gastroenterology·Ingeborg M J Bovee-OudenhovenRoelof Van Der Meer
Aug 17, 2004·American Journal of Physiology. Cell Physiology·Sadasivan VidyasagarHenry J Binder
Dec 14, 2004·American Journal of Physiology. Cell Physiology·Adrian Allen, Gunnar Flemström
Jan 29, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sadasivan VidyasagarVazhaikkurichi M Rajendran
Feb 9, 2005·Critical Reviews in Clinical Laboratory Sciences·Jacob Tfelt-Hansen, Edward M Brown
Mar 11, 2005·Journal of Clinical Gastroenterology·Henry J BinderJohn P Geibel
Jun 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·John GeibelSteven C Hebert
Aug 1, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yasutada AkibaJonathan D Kaunitz
Sep 4, 2009·The Journal of Clinical Investigation·Mary Abigail S GarciaPaul M Quinton
May 15, 2010·Lancet·Robert E BlackUNKNOWN Child Health Epidemiology Reference Group of WHO and UNICEF
May 15, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Colleen Talbot, Christian Lytle
Aug 10, 2010·The British Journal of Nutrition·Marloes A A SchepensIngeborg M J Bovee-Oudenhoven
Oct 12, 2010·American Journal of Physiology. Cell Physiology·Paul M Quinton
Dec 25, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yu WangRodger A Liddle
Jan 22, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alice P LiouStephen A Wank
Jul 5, 2011·Nature Reviews. Gastroenterology & Hepatology·Sean R MooreRichard L Guerrant
Nov 19, 2011·The Journal of Biological Chemistry·Osvaldo ReyEnrique Rozengurt
Apr 21, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sam X Cheng
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Kyra JonesDavid R Rose
Jan 25, 2013·Journal of Pediatric Gastroenterology and Nutrition·Sam X ChengFred S Gorelick

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Citations

Feb 17, 2017·Future Medicinal Chemistry·Pawin PongkorpsakolChatchai Muanprasat
Dec 29, 2015·Seminars in Cell & Developmental Biology·Jennifer L OwenMansour Mohamadzadeh
Aug 16, 2018·The British Journal of Nutrition·Guangmang LiuJing Wang
Feb 23, 2019·Physiological Reports·Joshua M SternSylvia O Suadicani
Nov 24, 2017·Pediatric Research·Jane E Harrell, Sam X Cheng
Oct 18, 2016·Current Opinion in Gastroenterology·Hyder Said, Jonathan D Kaunitz
Oct 3, 2018·World Journal of Gastroenterology : WJG·Luca IamartinoMartin Schepelmann
Mar 15, 2016·World Journal of Gastroenterology : WJG·Sam Xianjun Cheng
Dec 29, 2020·American Journal of Physiology. Cell Physiology·Krittikan ChanpaisaengNarattaphol Charoenphandhu
Apr 12, 2018·Journal of Agricultural and Food Chemistry·Hua Zhang, Yoshinori Mine

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