Calcium signal-dependent plasticity of neuronal excitability developed postnatally

Journal of Neurobiology
Mei ZhangJin-Hui Wang

Abstract

Neuronal plasticity and its development were investigated at pyramidal neurons in the cortical slices of rats. The threshold and probability of firing spikes were measured by using whole-cell recording to assess neuronal excitability. Postsynaptic high frequency activity (HFA) at the pyramidal neurons, evoked by 20 trains (250-ms interval) of five depolarization-pulses (1 ms) at 100 Hz, persistently lowered the threshold and increased the probability of firing spikes. After long-term enhancement of neuronal excitability by HFA was stable, another HFA induced further enhancement. Infusing 1 mM 1,2-bis(2-aminophenoxy)-ethane-N, N,N',N'-tetraacetic acid or 100 microM CaMKII(281-301) into the recording neurons prevented HFA-induced long-term enhancement of neuronal excitability. The infusion of 40 microM calcineurin autoinhibitory peptide enhanced neuronal excitability, which occluded HFA effect. HFA-induced long-term enhancement of intrinsic excitability expressed at most pyramidal neurons after postnatal day (PND) 14, but not at those before PND 9. Our results show a new type of neuronal plasticity induced by physiological activity at cortical neurons, which requires calcium-dependent protein phosphorylation and develops during p...Continue Reading

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Citations

Mar 14, 2007·Neural Computation·Jochen Triesch
Dec 9, 2008·Biochemical and Biophysical Research Communications·Qiyi WangJin-Hui Wang
Jun 8, 2006·Biochemical and Biophysical Research Communications·Na ChenJin-Hui Wang
May 9, 2006·Biochemical and Biophysical Research Communications·Sudong GuanJin-Hui Wang
Dec 14, 2005·Biochemical and Biophysical Research Communications·Na ChenJinhui Wang
Dec 13, 2007·Biochemical and Biophysical Research Communications·Shidi ZhaoJin-Hui Wang
Mar 1, 2018·F1000Research·Jin-Hui Wang, Shan Cui

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