Calcium signaling defects underlying salivary gland dysfunction

Biochimica Et Biophysica Acta. Molecular Cell Research
Indu S Ambudkar

Abstract

Salivary glands secrete saliva, a mixture of proteins and fluids, which plays an extremely important role in the maintenance of oral health. Loss of salivary secretion causes a dry mouth condition, xerostomia, which has numerous deleterious consequences including opportunistic infections within the oral cavity, difficulties in eating and swallowing food, and problems with speech. Saliva secretion is regulated by stimulation of specific signaling mechanisms within the acinar cells of the gland. Neurotransmitter-stimulated increase in cytosolic [Ca2+] ([Ca2+]i) in acinar cells is the primary trigger for salivary fluid secretion from salivary glands, the loss of which is a critical factor underlying dry mouth conditions in patients. The increase in [Ca2+]i regulates multiple ion channel and transport activities that together generate the osmotic gradient which drives fluid secretion across the apical membrane. Ca2+ entry mediated by the Store-Operated Ca2+ Entry (SOCE) mechanism provides the essential [Ca2+]i signals to trigger salivary gland fluid secretion. Under physiological conditions depletion of ER-Ca2+ stores is caused by activation of IP3R by IP3 and this provides the stimulus for SOCE. Core components of SOCE in salivary...Continue Reading

Citations

Jul 22, 2020·Journal of Cellular Biochemistry·Marcelo Marcet-PalaciosA D Befus
Nov 2, 2018·International Journal of Molecular Sciences·Muhammad Shahnawaz SoyfooChristine Delporte
Apr 2, 2020·Frontiers in Pharmacology·Mahmoud G KhalafallaGary A Weisman
May 8, 2020·JCI Insight·Juan Cortes-TroncosoIlias Alevizos
Oct 22, 2020·Cell Reports·Christine Silvia GibhardtIvan Bogeski
Apr 30, 2021·Nature Reviews. Rheumatology·Gwenny M VerstappenFrans G M Kroese
Nov 14, 2020·International Journal of Molecular Sciences·Ji-Youn KimJae-Kwang Jung
Jun 29, 2021·Frontiers in Oncology·María Paz SaldíasOscar Cerda
Nov 4, 2021·Scientific Reports·Riyuji YamashitaKazuhiro Nagata

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.