Calcium Signaling in Liver Injury and Regeneration

Frontiers in Medicine
Nuria Oliva-VilarnauVolker M Lauschke

Abstract

The liver fulfills central roles in metabolic control and detoxification and, as such, is continuously exposed to a plethora of insults. Importantly, the liver has a unique ability to regenerate and can completely recoup from most acute, non-iterative insults. However, multiple conditions, including viral hepatitis, non-alcoholic fatty liver disease (NAFLD), long-term alcohol abuse and chronic use of certain medications, can cause persistent injury in which the regenerative capacity eventually becomes dysfunctional, resulting in hepatic scaring and cirrhosis. Calcium is a versatile secondary messenger that regulates multiple hepatic functions, including lipid and carbohydrate metabolism, as well as bile secretion and choleresis. Accordingly, dysregulation of calcium signaling is a hallmark of both acute and chronic liver diseases. In addition, recent research implicates calcium transients as essential components of liver regeneration. In this review, we provide a comprehensive overview of the role of calcium signaling in liver health and disease and discuss the importance of calcium in the orchestration of the ensuing regenerative response. Furthermore, we highlight similarities and differences in spatiotemporal calcium regulat...Continue Reading

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Citations

Nov 20, 2020·Khirurgiia·A N Plekhanov, A I Tovarshinov
Jan 3, 2021·Cell Calcium·Béatrice MorioJennifer Rieusset
Jan 6, 2021·Journal of Cell Communication and Signaling·Andrés Hernández-OliverasJuan Santiago-García
Feb 3, 2021·Journal of Clinical Medicine·Salvador ResinoMaría A Jiménez-Sousa

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BETA
transgenic

Clinical Trials Mentioned

NCT00771901
NCT00533559
NCT03331432

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