Calcium signaling pathway is involved in non-CYP51 azole resistance in Aspergillus fumigatus

Medical Mycology
Yeqi LiLing Lu

Abstract

The opportunistic fungal pathogen Aspergillus fumigatus, which is one of the primary airborne ascomycete pathogens and allergens worldwide, causes invasive fungal infections, which have high morbidity and mortality rates among immunosuppressed patients. The abuse of azole antifungals results in serious drug resistance in clinical therapy. Thus, a thorough understanding of the azole drug resistance mechanism and screening of antifungal agents with a novel mode of action and new drug targets are required to fight against drug resistance. Current studies suggest that there are three major azole resistance mechanisms in fungal pathogens, including changes of the drug target Cyp51, activation of drug efflux pumps and induction of cellular stress responses. Fungi must adapt to a variety of external environmental stressors to survive. These obstacles include stress to the plasma membrane after azole antifungal treatments, high temperature, pH variation, and oxidative stress. As a filamentous fungus, A. fumigatus has evolved numerous signal-transduction systems to sense and respond to azole stresses to survive and proliferate in harsh environmental conditions. Among these signal-transduction systems, the Ca2+ signaling pathway is one o...Continue Reading

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Citations

Dec 8, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yeqi LiLing Lu
Aug 9, 2020·Molecular Microbiology·Jinxing SongRongpeng Li
Feb 26, 2021·Mycology·Avishek RoyRanjan Tamuli

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