Jun 17, 2010

Calcium signaling through CatSper channels in mammalian fertilization

Physiology
Dejian Ren, Jingsheng Xia

Abstract

The molecular mechanisms underlying Ca(2+) entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca(2+) entry through CatSper channels instead of acting on Ca(V) and CNG channels as previously thought.

  • References100
  • Citations64

Citations

Mentioned in this Paper

Fertility
Cell Motility
Infertility Study
Calcium Signaling
Motility
Calcium Channel
Ion Channel
Mice, Knockout
Fertilization
CATSPER1 gene

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