Calcium signalling and calcium transport in bone disease

Sub-cellular Biochemistry
Harry C BlairM Zaidi

Abstract

Calcium transport and calcium signalling mechanisms in bone cells have, in many cases, been discovered by study of diseases with disordered bone metabolism. Calcium matrix deposition is driven primarily by phosphate production, and disorders in bone deposition include abnormalities in membrane phosphate transport such as in chondrocalcinosis, and defects in phosphate-producing enzymes such as in hypophosphatasia. Matrix removal is driven by acidification, which dissolves the mineral. Disorders in calcium removal from bone matrix by osteoclasts cause osteopetrosis. On the other hand, although bone is central to management of extracellular calcium, bone is not a major calcium sensing organ, although calcium sensing proteins are expressed in both osteoblasts and osteoclasts. Intracellular calcium signals are involved in secondary control including cellular motility and survival, but the relationship of these findings to specific diseases is not clear. Intracellular calcium signals may regulate the balance of cell survival versus proliferation or anabolic functional response as part of signalling cascades that integrate the response to primary signals via cell stretch, estrogen, tyrosine kinase, and tumor necrosis factor receptors.

Citations

Aug 8, 2008·Journal of Cellular Physiology·Jianwen WeiDouglas R Cavener
Sep 30, 2010·Journal of Biomaterials Applications·Masahiro YamadaTakahiro Ogawa
Sep 17, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hellen ZhengWolf-Dietrich Hübner
Jan 31, 2020·Calcified Tissue International·Edek A J WilliamsJ Christopher Fritton
Sep 15, 2010·Journal of Cellular Physiology·Yandong ZhouJohn B Barnett
Jun 24, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L CianferottiM L Brandi
Mar 21, 2017·The Journal of Endocrinology·Nicholaos I PapachristouDionysios J Papachristou
Feb 19, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wenfeng XuXiaoling Liao
Nov 24, 2017·International Journal of Environmental Research and Public Health·Wojciech RoczniakMagdalena Babuśka-Roczniak
Sep 27, 2019·Annals of the New York Academy of Sciences·Fawzy Ali Saad
Apr 10, 2019·Nature Communications·Jianwei LiYingxian Li
Feb 13, 2014·Experimental and Therapeutic Medicine·Baixiang WangJingyun Wang
Nov 9, 2011·Molecular and Cellular Biology·Aditi Mukherjee, Peter Rotwein
Mar 18, 2011·Journal of Cellular Physiology·Li LiuHarry C Blair
Apr 16, 2010·Annals of the New York Academy of Sciences·Lisa J RobinsonChristopher L-H Huang
Dec 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sung-Yong Hwang, James W Putney
Jan 6, 2018·Tissue Engineering. Part B, Reviews·Xuening ChenHongjun Wang
Aug 29, 2018·International Journal of Biomaterials·Yong-Seok JangMin-Ho Lee
Aug 28, 2020·Frontiers in Endocrinology·Francesca TonelliAntonella Forlino
Jun 8, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·M MohedanoE Matykina
Jan 21, 2021·International Journal of Molecular Sciences·Nigel De MeloVirginie Sottile
Dec 16, 2020·ACS Biomaterials Science & Engineering·Rita GelliFrancesca Ridi
May 8, 2021·World Journal of Stem Cells·Nassem Ahamad, Brij B Singh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Tetsushi Furukawa
Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
Ulf H. Lerner
Current Rheumatology Reports
Ana Rita Couto, Matthew A Brown
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Morten A KarsdalKim Henriksen
Seminars in Cell & Developmental Biology
Gudrun Stenbeck
© 2021 Meta ULC. All rights reserved