Calcium silicate as a graft material for bone fractures: a systematic review

The Journal of International Medical Research
Marcelo Sanmartin de AlmeidaJosé Mauro Granjeiro

Abstract

Objective The goal of this review was to determine whether calcium silicate (wollastonite) as a bone graft material is a viable alternative to autogenous bone or whether the evidence base for its use is weak. Methods In this systematic review, electronic databases (MEDLINE/PubMed and BVS) were searched for relevant articles in indexed journals. Articles published in a 10-year period were identified (n = 48). After initial selection, 17 articles were assessed for eligibility; subsequently, seven articles were excluded and 10 articles were included. Results Among the studies included, 20% emphasized the importance of randomization, which adds reliability to the study, minimizing the risk of bias. High variability was observed in the material used, such as additives, amounts, dosage, and chemical alterations, rendering direct comparison among these studies impossible. The experimental periods varied considerably; one of the studies did not include statistical analysis, weakening the evaluation. Nonetheless, the true potential of wollastonite as a graft material conducive to new bone formation was reported in all studies. Conclusion The results support the use of wollastonite as a bone graft material. The initial research question ...Continue Reading

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Citations

Sep 7, 2019·Biomedical Materials·Rui GeYuancheng Li
Jun 27, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Hanxu ZhangHuixin Liang
Aug 27, 2021·Biomedical Physics & Engineering Express·Maedeh RahimnejadRodrigo França
Nov 26, 2021·Frontiers in Bioengineering and Biotechnology·Philip ProcterSune Larsson

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Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

Cochrane
GraphPad Prism

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