Calcium sulfate spinal cord scaffold: a study on degradation and fibroblast growth factor 1 loading and release

Journal of Biomaterials Applications
Jonas ÅbergHåkan Engqvist

Abstract

Currently, there is no regenerative strategy for the spinal cord that is part of clinical standard of core. Current paths usually include combinations of scaffold materials and active molecules. In a recent study, a permanent dental resin scaffold for treatment of spinal cord injury was designed. The results from studies on rats were promising. However, for potential clinical use, a biodegradable scaffold material that facilitates drug delivery and the regeneration of the spinal cord needs to be developed. Also a biodegradable material is expected to allow a better evaluation of the efficacy of the surgical method. In this article, the suitability of hardened calcium sulfate cement (CSC) for use as degradable spinal cord scaffolds is investigated in bench studies and in vitro studies. Compressive strength, degradation and microstructure, and the loading capability of heparin-activated fibroblast growth factor 1 (FGF1) via soaking were evaluated. The CSC could easily be injected into the scaffold mold and the obtained scaffolds had sufficient strength to endure the loads applied during surgery. When hardened, the CSC formed a porous microstructure suitable for loading of active substances. It was shown that 10 min of FGF1 soakin...Continue Reading

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Citations

Sep 12, 2012·Journal of Biomedical Materials Research. Part a·Matthew E BrownDavid A Puleo

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Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assay
ELISA
Assay

Software Mentioned

Magellan

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