Calcium supplementation does not alter lipid oxidation or lipolysis in overweight/obese women

Obesity
Vanitha SampathJanet C King

Abstract

Based on cell culture and studies in mice, increased dietary calcium appears to stimulate lipolysis and could possibly reduce body adiposity through hormonal influences on adipocyte calcium uptake. In this study, we investigated the effects of 1,500 mg supplemental calcium daily for 3 months on hormones regulating calcium and energy metabolism and rates of lipid oxidation and lipolysis in overweight women. Fifteen overweight (BMI > 25 kg/m(2)) premenopausal women were supplemented with 1,500 mg of calcium, as CaCO(3), per day for 3 months while maintaining their usual diets and activity levels. Baseline and endpoint measurements were obtained after the subjects consumed a standardized 25% fat diet for 4 days. Lipid oxidation was measured by indirect calorimetry, lipolysis by infusion of deuterated glycerol, and body fat by dual-energy X-ray absorptiometry. Urinary calcium, circulating levels of hormones involved in energy and lipid metabolism (insulin, leptin, and adiponectin) or calcium metabolism (25(OH)D, 1,25(OH)(2)D), and parathyroid hormone (PTH)) were also measured. Urinary levels of calcium (P = 0.005) increased and 1,25(OH)(2)D declined (P = 0.03). However other parameters, including body weight, body fat, PTH, insulin...Continue Reading

References

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Citations

May 17, 2012·Nutrition Research Reviews·Qingming Song, Igor N Sergeev
Sep 14, 2010·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·L H M Leite, A B M M Sampaio
Jun 20, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J T GonzalezE J Stevenson
Feb 15, 2012·Journal of the American College of Nutrition·Megan L SkinnerAndrea C Buchholz
Jul 11, 2009·Journal of the American College of Nutrition·Marta Van Loan
Apr 30, 2015·The Cochrane Database of Systematic Reviews·Pranom BuppasiriNancy Medley

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