PMID: 11903960Mar 21, 2002Paper

Calcium supplementation efficiently reduces lead absorption in suckling rats

Pharmacology & Toxicology
V M VarnaiK Kostial

Abstract

The effect of calcium supplementation on tissue lead was evaluated in suckling Wistar rats. Such data are not yet available in the literature. The following artificial feeding regimen was used for calcium supplementation: cow's milk by addition of 1%, 3% or 6% Ca as CaHPO(4)x2H(2)O suspension to increase the daily calcium intake about 1.4, 2 or 3 times above control values. Artificial feeding was applied during 7 hr each day for nine consecutive days (from day 6 through 15 after birth). The effect of such treatment on lead absorption and elimination was evaluated in two separate experiments: calcium supplementation during oral lead exposure (as acetate; daily dose 2 mg Pb/kg body wt.; total Pb dose 18 mg/kg body wt.) or after a single intraperitoneal lead administration (5 mg/kg body wt.). At the end of experiments, lead in tissues (liver, kidneys, brain and carcass), and essential elements (Ca, Fe, Zn, Cu) were analysed by atomic absorption spectrometry. Calcium supplementation caused a statistically significant decrease of lead in all tissues of sucklings orally exposed to lead. This decrease was dose-related being about 1.3, 1.5 and 2 times lower in groups supplemented with 1%, 3%, or 6% calcium compared to controls, respect...Continue Reading

Citations

Sep 5, 2002·Journal of Applied Toxicology : JAT·Vilena KasubaMaja Blanusa
Aug 2, 2012·International Journal of Environmental Research and Public Health·Yuelin YangPin Sun
Jul 11, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·F MouchetL Gauthier
Oct 15, 2005·Toxicology and Applied Pharmacology·G E Cortina-RamírezJ V Calderón-Salinas
Apr 8, 2016·Ecotoxicology and Environmental Safety·Carlucio Rocha Dos SantosRita De Cássia Oliveira Da Costa Mattos
Apr 30, 2020·Environmental Science and Pollution Research International·Jennifer Pareja-CarreraMónica Martinez-Haro
Nov 30, 2019·Journal of Environmental and Public Health·Conrad Krebs
Apr 4, 2021·International Journal of Molecular Sciences·Svetlana V KlinovaYuri L Protsenko
Aug 10, 2021·Environmental Science and Pollution Research International·József LehelPéter Budai

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