Calcium transient evoked by TRPV1 activators is enhanced by tumor necrosis factor-{alpha} in rat pulmonary sensory neurons.

American Journal of Physiology. Lung Cellular and Molecular Physiology
Youmin HuLu-Yuan Lee

Abstract

TNFα, a proinflammatory cytokine known to be involved in the pathogenesis of allergic asthma, has been shown to induce hyperalgesia in somatic tissue via a sensitizing effect on dorsal root ganglion neurons expressing transient receptor potential vanilloid type 1 receptor (TRPV1). Because TRPV1-expressing pulmonary sensory neurons play an important role in regulating airway function, this study was carried out to determine whether TNFα alters the sensitivity of these neurons to chemical activators. Responses of isolated nodose and jugular ganglion neurons innervating the rat lungs were determined by measuring the transient increase in intracellular Ca(2+) concentration ([Ca(2+)](i)). Our results showed the following. 1) A pretreatment with TNFα (50 ng/ml) for ∼24 h increased significantly the peak Δ[Ca(2+)](i) evoked by capsaicin (Cap) in these neurons. A pretreatment with the same concentration of TNFα for a longer duration (∼48 h) did not further increase the response, but pretreatment for a shorter duration (1 h) or with a lower concentration (25 ng/ml, 24 h) failed to enhance the Cap sensitivity. 2) The same TNFα pretreatment also induced similar but less pronounced and less uniform increases in the responses to acid (pH 6....Continue Reading

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Citations

Mar 15, 2011·Respiratory Physiology & Neurobiology·Yu Ru KouLu-Yuan Lee
Feb 24, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cheng ZhangLu-Yuan Lee
May 20, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chun-Chun HsuLu-Yuan Lee
Aug 16, 2018·Physiological Reviews·Colin ReardonAlan E Lomax
Apr 14, 2012·The Journal of Veterinary Medical Science·Yukitoshi MakimuraHirokazu Tsubone
Jul 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chun-Chun HsuYou Shuei Lin
Jul 25, 2019·International Journal of Molecular Sciences·Yasunori TakayamaMakoto Tominaga
Jun 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lei ZhaoFadi Xu
Jun 16, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiuping GaoFadi Xu
Mar 30, 2013·Journal of Applied Physiology·Ruei-Lung LinLu-Yuan Lee
Jul 1, 2017·Frontiers in Physiology·Ruei-Lung LinLu-Yuan Lee
Oct 22, 2019·Frontiers in Cellular Neuroscience·Asmita DhukhwaDebashree Mukherjea
Jan 16, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ruei-Lung LinLu-Yuan Lee
Sep 4, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yu-Jung LinLu-Yuan Lee
Feb 16, 2021·Neuroscience Letters·Qihai Gu, Lu-Yuan Lee
Apr 19, 2011·Biochimica Et Biophysica Acta·Sophie A van DiestRené M van den Wijngaard

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