Calcium transport in strongly calcifying laying birds: mechanisms and regulation

Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Arie Bar


Birds that lay long clutches (series of eggs laid sequentially before a "pause day"), among them the high-producing, strongly-calcifying Gallus gallus domesticus (domestic hen) and Coturnix coturnix japonica (Japanese quail), transfer about 10% of their total body calcium daily. They appear, therefore, to be the most efficient calcium-transporters among vertebrates. Such intensive transport imposes severe demands on ionic calcium (Ca2+) homeostasis, and activates at least two extremely effective mechanisms for Ca2+ transfer from food and bone to the eggshell. This review focuses on the development, action and regulation of the mechanisms associated with paracellular and transcellular Ca2+ transport in the intestine and the eggshell gland (ESG); it also considers some of the proteins (calbindin, Ca2+ATPase, Na+/Ca2+ exchange, epithelial calcium channels (TRPVs), osteopontin and carbonic anhydrase (CA) associated with this phenomenon. Calbindins are discussed in some detail, as they appear to be a major component of the transcellular transport system, and as only they have been studied extensively in birds. The review aims to gather old and new knowledge, which could form a conceptual basis, albeit not a completely accepted one, ...Continue Reading


Sep 1, 1976·British Poultry Science·P Mongin
Jun 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·C S FullmerR H Wasserman
Nov 10, 1975·Biochimica Et Biophysica Acta·A BarS Edelstein
Jan 1, 1978·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A BarS HURWITZ
Sep 1, 1977·Poultry Science·M A MusslerK E Nestor
Feb 1, 1978·General and Comparative Endocrinology·R T Turner, L P Eliel
Nov 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·R H Wasserman, G F Combs
Oct 1, 1978·Biology of Reproduction·W C Eastin, E Spaziani
Oct 1, 1978·Biology of Reproduction·W C Eastin, E Spaziani
Nov 1, 1976·Poultry Science·A A Grunder, K G Hollands
Nov 1, 1976·The Journal of Endocrinology·C G Dacke
Feb 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L Lippiello, R H Wasserman
Apr 1, 1975·Endocrinology·N A ShahabiA V Nalbandov
Apr 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·A BarS Striem
Sep 1, 1990·Pflügers Archiv : European journal of physiology·J L BorkeR Kumar
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A BillecocqR Baron
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S ChandraG H Morrison
Jan 1, 1989·Connective Tissue Research·W T Butler
Jun 1, 1989·British Poultry Science·D WaddingtonA B Gilbert
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W Hunziker
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C S Fullmer, R H Wasserman
Jun 1, 1973·Comparative Biochemistry and Physiology. A, Comparative Physiology·A Bar, S HURWITZ
Dec 1, 1974·Comparative Biochemistry and Physiology. A, Comparative Physiology·I Cohen, S HURWITZ
Apr 15, 1972·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A Bar, S HURWITZ
Sep 5, 1973·Biochemical and Biophysical Research Communications·A Bar, R H Wasserman
Jan 1, 1972·Poultry Science·J W RieserW H Burke
Jul 1, 1973·British Poultry Science·N B HaynesM J Kay
Jan 1, 1969·Biochimica Et Biophysica Acta·A Bar, S HURWITZ
Feb 1, 1967·Journal of Reproduction and Fertility·M H el Jack, P E Lake
Nov 1, 1967·Poultry Science·S HURWITZ, A Bar
Nov 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·G EhrenspeckR Schraer
Jun 1, 1983·The Proceedings of the Nutrition Society·A B Gilbert
Apr 21, 1983·Biochimica Et Biophysica Acta·W E GhijsenCarel H Van Os
Nov 1, 1984·Endocrinology·J P van de VeldeJ P Vermeiden
Jun 13, 1984·Biochimica Et Biophysica Acta·J J Feher
Nov 1, 1980·The Journal of Clinical Investigation·H James ArmbrechtB B Davis
Jan 1, 1980·Reproduction, Nutrition, Development·Y Nys, P Mongin
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Q CaiJ T Penniston
Oct 12, 1994·Biochimica Et Biophysica Acta·H James ArmbrechtN Wongsurawat
Feb 1, 1996·Critical Reviews in Biochemistry and Molecular Biology·S HURWITZ
Dec 1, 1995·Matrix Biology : Journal of the International Society for Matrix Biology·M PinesA Bar
Dec 1, 1995·Poultry Science·J H SoaresR W Gray
Aug 1, 1996·Histochemistry and Cell Biology·C S FullmerR H Wasserman
Jul 1, 1997·Baillière's Clinical Endocrinology and Metabolism·Roger BouillonS Boonen
Jan 29, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·I LavelinM Pines
Apr 24, 1999·Experimental Nephrology·S R Rittling, D T Denhardt
Jul 30, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A BarS Striem
Jul 13, 2000·British Poultry Science·L HolmY Ridderstråle
Jul 20, 2000·Poultry Science·I LavelinM Pines
Jul 20, 2000·Poultry Science·H M Edwards
Oct 6, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J SodekM D McKee
Nov 4, 2000·Biochemical and Biophysical Research Communications·Paul GlendenningE E Strehler
Nov 30, 2000·Pharmacology & Toxicology·C Hemmingsen
Feb 27, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·M Soledad FernandezJ I Arias
Dec 14, 2001·Biochemical and Biophysical Research Communications·K WeberJ Adamski
May 9, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·P M Ingleton
Jun 1, 2002·Molecular Endocrinology·David G MonroeMichel M Sanders
Jul 12, 2002·Journal of Cellular Biochemistry·Ilka Nemere, D Larsson
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I LavelinM Pines
Jan 10, 2003·Journal of Cellular Biochemistry·Sylvia ChristakosX Peng
Jan 10, 2003·Journal of Cellular Biochemistry·Michael F Holick
Jan 10, 2003·Journal of Cellular Biochemistry·Roger BouillonGeert Carmeliet
Jan 10, 2003·Journal of Cellular Biochemistry·Felix Bronner
Feb 6, 2003·The British Journal of Nutrition·Arie BarIsaac Plavnik
Feb 25, 2003·Annual Review of Biophysics and Biomolecular Structure·David L Stokes, N Michael Green
Mar 4, 1961·Nature·S HURWITZ, P GRIMINGER
Jan 1, 1965·Canadian Journal of Physiology and Pharmacology·C F CRAMER
Oct 31, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S J Van CromphautGeert Carmeliet
Feb 6, 2004·Journal of Electron Microscopy·Ichiro NakamuraLe T Duong
Nov 1, 1951·Archives of Biochemistry and Biophysics·B B MIGICOVSKY, A M NIELSON
May 5, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Vibeke Sødring ElbrøndErik Skadhauge
May 21, 2004·American Journal of Physiology. Cell Physiology·Eveline E Schneeberger, Robert D Lynch
Sep 15, 2004·Journal of Structural Biology·M S FernandezJ L Arias
Nov 6, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Viviana A CentenoNori G Tolosa de Talamoni
Nov 16, 2004·Cell Calcium·Louiza BelkacemiJulie Lafond
Dec 25, 2004·Physiological Reviews·Joost G J HoenderopRené J M Bindels
Jan 27, 2005·The Journal of Experimental Biology·Alisen E Vetter, Scott M O'Grady
Feb 9, 2005·British Poultry Science·R Braw-TalA Bar
Mar 5, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Monique Van AbelRené J M Bindels
Apr 12, 2005·Archives of Biochemistry and Biophysics·Alex J BrownH James Armbrecht
May 13, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Barbara A Niemeyer
May 14, 2005·Annals of the New York Academy of Sciences·P J Sharp
Jun 14, 2005·American Journal of Physiology. Renal Physiology·Adriana S DussoEduardo Slatopolsky
Jul 27, 2005·Pflügers Archiv : European journal of physiology·Tom NijenhuisRené J M Bindels
Nov 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bram C J van der EerdenJohannes P T M van Leeuwen
Dec 20, 2005·Gene·Janet RubinChristopher Rae Jacobs
Jan 21, 2006·The Journal of Endocrinology·John T Potts
Feb 8, 2006·Annual Review of Physiology·Christina M Van Itallie, James M Anderson
Mar 7, 2006·Kidney International·Tim T LambersJoost G J Hoenderop
Mar 8, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Indra Ramasamy
May 6, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Narattaphol CharoenphandhuNateetip Krishnamra
May 9, 2006·Respiratory Physiology & Neurobiology·A J Esbaugh, B L Tufts
Jun 10, 2006·The EMBO Journal·Tim T LambersRené J M Bindels
Dec 8, 2006·Proteomics·Karlheinz MannMatthias Mann
Dec 14, 2006·Kidney International·J M Purkerson, G J Schwartz
Jan 17, 2007·Archives of Biochemistry and Biophysics·Shirin AkhterHector F DeLuca
Jan 20, 2007·Biochemical Society Transactions·J P H SchoeberRené J M Bindels
Jun 21, 2007·Annual Review of Biochemistry·Kartik Venkatachalam, Craig Montell
Mar 18, 1949·Science·C L Comar, J C Driggers
May 6, 1966·Science·R H Wasserman, A N Taylor
Dec 18, 2007·Annals of the New York Academy of Sciences·Sylvia ChristakosSneha Joshi
Dec 28, 2007·General and Comparative Endocrinology·Roy V Talmage, H T Mobley
Jul 5, 2008·Annual Review of Nutrition·Ramesh C Khanal, Ilka Nemere
Aug 14, 2008·Cells, Tissues, Organs·Y-C ChienM D McKee


Mar 29, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·André G OliveiraCleida A Oliveira
Jun 20, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Adrienne C BautistaRobert H Poppenga
Jan 17, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jill A HadleyR M Leach
Jul 21, 2012·General and Comparative Endocrinology·Kannikar Wongdee, Narattaphol Charoenphandhu
Jul 24, 2012·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Santiago P FregosoTom W Ecay
Jun 4, 2014·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Claudia A CrespoSilvia N Fernández
Dec 3, 2014·General and Comparative Endocrinology·Ashutosh KumarChandan Goswami
Sep 11, 2014·Bone·Michael KerschnitzkiWolfgang Wagermaier
May 31, 2011·Life Sciences·André G Oliveira, Cleida A Oliveira
Nov 22, 2017·Archives of Insect Biochemistry and Physiology·Austin Browne, Michael J O'Donnell
Dec 5, 2017·Animal : an International Journal of Animal Bioscience·A S ValableM P Létourneau-Montminy
Jan 8, 2011·Reproduction, Fertility, and Development·G MaurerP Cassey
Apr 1, 2020·Anatomia, histologia, embryologia·Mary-Cathrine Madekurozwa, Mike M Mpango
Jul 29, 2020·BMC Genomics·Sandra Poyatos PertiñezI C Dunn
Sep 18, 2020·Animals : an Open Access Journal From MDPI·Simon JansenSteffen Weigend
Feb 14, 2021·BMC Molecular and Cell Biology·J GautronM T Hincke
Jan 9, 2021·Tropical Animal Health and Production·Abbass AshooriMohammad Jafari

Related Concepts

Japanese Quail
Patient Transfer
Skeletal Bone
Calcium ion

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.