PMID: 8978723Jan 1, 1997Paper

Calcium/calmodulin-dependent kinase II phosphorylates Drosophila visual arrestin

Journal of Neurochemistry
E S Kahn, H Matsumoto

Abstract

Light activation of rhodopsin in the Drosophila photoreceptor induces a G protein-coupled signaling cascade that results in the influx of Ca2+ into the photoreceptor cells. Immediately following light activation, phosphorylation of a photoreceptor-specific protein, phosrestin I, is detected. Strong sequence similarity to mammalian arrestin and electroretinograms of phosrestin mutants suggest that phosrestin I is involved in light inactivation. We are interested in identifying the protein kinase responsible for the phosphorylation of phosrestin I to link the transmembrane signaling to the light-adaptive response. Type II Ca2+/calmodulin-dependent kinase is one of the major classes of protein kinases that regulate cellular responses to transmembrane signals. We show here that partially purified phosrestin I kinase activity can be immunodepleted and immunodetected with antibodies to Ca2+/calmodulin-dependent kinase II and that the kinase activity exhibits regulatory properties that are unique to Ca2+/calmodulin-dependent kinase II such as Ca2+ independence after autophosphorylation and inhibition by synthetic peptides containing the Ca2+/calmodulin-dependent kinase II autoinhibitory domain. We also show that Ca2+/calmodulin-depend...Continue Reading

Citations

Feb 15, 2003·Archives of Insect Biochemistry and Physiology·Sandra Braak, Michael Fährmann
Dec 28, 1999·Annual Review of Cell and Developmental Biology·C Montell
May 10, 2007·Pflügers Archiv : European journal of physiology·Tao Wang, Craig Montell
Mar 17, 2012·Journal of Neurogenetics·Hung-Tat LeungEunju Kim
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·P G Alloway, P J Dolph
Mar 4, 2009·The Journal of Biological Chemistry·Haiqin LuBih-Hwa Shieh
Aug 4, 1998·Current Opinion in Neurobiology·C Montell
Oct 27, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·E S KahnH Matsumoto
Feb 21, 2002·Biochimica Et Biophysica Acta·Michael FährmannGernot Beinbrech
Oct 17, 2001·Cellular Signalling·P H McDonald, R J Lefkowitz

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