Calcium/calmodulin-dependent protein kinase IV: A multifunctional enzyme and potential therapeutic target

Progress in Biophysics and Molecular Biology
Huma NazMd Imtaiyaz Hassan

Abstract

The calcium/calmodulin-dependent protein kinase IV (CAMKIV) belongs to the serine/threonine protein kinase family, and is primarily involved in transcriptional regulation in lymphocytes, neurons and male germ cells. CAMKIV operates the signaling cascade and regulates activity of several transcription activators by phosphorylation, which in turn plays pivotal roles in immune response, inflammation and memory consolidation. In this review, we tried to focus on different aspects of CAMKIV to understand the significance of this protein in the biological system. This enzyme is associated with varieties of disorders such as cerebral hypoxia, azoospermia, endometrial and ovarian cancer, systemic lupus, etc., and hence it is considered as a potential therapeutic target. Structure of CAMKIV is comprised of five distinct domains in which kinase domain is responsible for enzyme activity. CAMKIV is involved in varieties of cellular functions such as regulation of gene expression, T-cell maturation, regulation of survival phase of dendritic cells, bone growth and metabolism, memory consolidation, sperm motility, regulation of microtubule dynamics, cell-cycle progression and apoptosis. In this review, we performed an extensive analysis on st...Continue Reading

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Citations

Aug 22, 2016·Molecular Neurobiology·Neha SamiImtaiyaz Hassan
Mar 14, 2017·Nature Reviews. Nephrology·Abel Suárez-FueyoGeorge C Tsokos
Aug 17, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kellie E CunninghamKevin P Mollen
Dec 23, 2017·Journal of Biomolecular Structure & Dynamics·Sunayana Begum SyedMd Imtaiyaz Hassan
Jan 7, 2020·Current Topics in Medicinal Chemistry·Ahmad Abu Turab NaqviMd Imtaiyaz Hassan
Feb 26, 2020·International Journal of Molecular Sciences·Jowita RzajewElzbieta Rebas
Jul 30, 2020·Oxidative Medicine and Cellular Longevity·Preeti GuptaMd Imtaiyaz Hassan
Sep 8, 2017·Molecular Neuropsychiatry·Verônica M Saia-CeredaDaniel Martins-de-Souza
Dec 15, 2020·Food Chemistry·Arichaya MalisonSuwimon Keeratipibul
Jul 31, 2020·Physiological Reviews·John C ChathamAdam R Wende
May 1, 2021·International Journal of Molecular Sciences·Kinga SałaciakKarolina Pytka
May 29, 2021·Journal of Cancer Research and Clinical Oncology·Azaj AhmedMd Imtaiyaz Hassan
Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Rahima BegumMd Sahab Uddin

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