PMID: 9445191Jan 28, 1998Paper

Calculated prostate carcinoma volume: The optimal predictor of 3-year prostate specific antigen (PSA) failure free survival after surgery or radiation therapy of patients with pretreatment PSA levels of 4-20 nanograms per milliliter

Cancer
A V D'AmicoC N Coleman

Abstract

In this study, the authors evaluated whether a clinically relevant stratification of prostate specific antigen (PSA) failure free survival (bNED) after definitive local therapy could be made for patients with prostate carcinoma clinically classified as T1 or T2 and pretreatment PSA levels of 4-20 ng/mL. Multivariate Cox regression analysis and Kaplan-Meier analysis were performed for clinically localized prostate carcinoma patients who presented with PSA levels of 4-20 ng/mL. Three hundred forty-eight of the patients were managed definitively with conventional external beam radiation therapy (median dose, 67 gray), whereas 547 of the patients were managed definitively with a radical retropubic prostatectomy. The outcome tested was time to posttreatment PSA failure. The clinical predictors evaluated included the standard paradigm (PSA, biopsy Gleason score, and clinical stage); type of local therapy; and a newly defined factor, the calculated prostate cancer volume (cV[Ca]). Time to posttreatment PSA failure was equivalent (P = 0.52) independent of the type of local therapy. The cV(Ca) (P < 0.0001), pretreatment PSA (P = 0.003), and clinical classification of T2c (P = 0.04) remained significant predictors of time to posttreatmen...Continue Reading

References

Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W R LeeM A Hunt
May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
Nov 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T M PisanskyJ E Oesterling
Apr 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A V D'AmicoA Wein
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·S P LankfordG K Zagars

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Citations

Aug 18, 2020·Biomarkers in Medicine·Ioannis PapasotiriouKlaus-Peter Jünemann
Nov 17, 2019·Life Science Alliance·Marina PinskayaAntonin Morillon
May 29, 2007·The American Journal of Surgical Pathology·Rebecca A MarksLiang Cheng
Jun 6, 2017·F1000Research·Venkatesh VaidyanathanLynnette R Ferguson
May 15, 2002·Critical Reviews in Oncology/hematology·Ulka Vaishampayan, Maha Hussain

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