PMID: 8583328Nov 1, 1995Paper

Calculation of biliary atresia prognostic index using a multivariate linear model

Journal of Pediatric Surgery
M EndoM Kitajima

Abstract

The purpose of this study was to determine the relative value of liver function markers in predicting the magnitude of morbidity and to develop a quantitative estimate of the prognostic risk using a multivariate regression model in patients who have been operated on for biliary atresia. The study sample consisted of 37 patients who had undergone a Kasai portoenterostomy; the jaundice disappeared in 32 and persisted in five. A computer-based stepwise regression procedure produced the linear predictive models by the equation: biliary atresia prognostic index (BAPI) = 9.2 Cu:Zn + 1.0 ZTT + 3.2 TB - 0.05 ChE + 9.9 for infants under 1 year of age, and BAPI = 10.3 Cu:Zn + 0.8 ZTT + 0.03 GGTP - 0.12 ChE + 25.6 for children over 1 year of age. In validation of these models, the indexes fluctuated from -17 to 122, and the degree of morbidity increased linearly with the increase in BAPI. Postoperatively the patients were classified into four categories according to the dynamics of their postoperative course: A (BAPI < 25), successful cases that should not require liver transplantation (40.5%); B (25 < or = BAPI < or = 50), improved cases that have extended survival with their native liver (29.7%); C (50 < BAPI < or = 75), cases that impr...Continue Reading

References

Jun 1, 1992·Journal of Pediatric Surgery·J N LinJ H Chuang
Sep 1, 1989·Journal of Pediatric Surgery·M KasaiR Ohi
Jan 1, 1989·Journal of Pediatric Surgery·J Vazquez-EstevezJ R Lilly
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E R DicksonA Langworthy
Feb 1, 1989·Archives of Disease in Childhood·R H HouwenC M Bijleveld
Oct 1, 1987·The Journal of Pediatrics·J J MalatackB W Shaw
Apr 1, 1985·World Journal of Surgery·R OhiM Kasai
Nov 1, 1983·Seminars in Liver Disease·N McIntyre
Jul 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J B OtteB Debande

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Citations

Dec 25, 2004·Pediatric Surgery International·Sittisak HonsawekYong Poovorawan
Jul 16, 2003·Journal of Pediatric Surgery·Masato ShinkaiToshiji Nishi
Jun 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Ronald J SokolFrederick M Karrer
May 14, 2008·Current Opinion in Pediatrics·Jonathan P Roach, Jennifer L Bruny
Apr 6, 2016·Journal of Indian Association of Pediatric Surgeons·Vikram KhannaManoj Kumar Singh
Jun 24, 2004·Journal of Pediatric Surgery·Keiichi UchidaMasato Kusunoki
Dec 27, 2005·Clinics in Liver Disease·Claus Petersen

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