Calculation of cerebral perfusion parameters using regional arterial input functions identified by factor analysis

Journal of Magnetic Resonance Imaging : JMRI
Linda KnutssonR Wirestam

Abstract

To calculate regional cerebral blood volume (rCBV), regional cerebral blood flow (rCBF), and regional mean transit time (rMTT) accurately, an arterial input function (AIF) is required. In this study we identified a number of AIFs using factor analysis of dynamic studies (FADS), and performed the cerebral perfusion calculation pixel by pixel using the AIF that was located geometrically closest to a certain voxel. To verify the robustness of the method, simulated images were generated in which dispersion or delay was added in some arteries and in the corresponding cerebral gray matter (GM), white matter (WM), and ischemic tissue. Thereafter, AIFs were determined using the FADS method and simulations were performed using different signal-to-noise ratios (SNRs). Simulations were also carried out using an AIF from a single pixel that was manually selected. In vivo results were obtained from normal volunteers and patients. The FADS method reduced the underestimation of rCBF due to dispersion or delay that often occurs when only one AIF represents the entire brain. This study indicates that the use of FADS and the nearest-AIF method is preferable to manual selection of one single AIF.

References

May 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B R RosenT J Brady
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L OstergaardB R Rosen
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L OstergaardB R Rosen
May 9, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R WirestamF Ståhlberg
Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F CalamanteA Connelly
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M J van OschM A Viergever
Apr 23, 2002·NMR in Biomedicine·Linda AnderssonFreddy Ståhlberg
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ona WuA Gregory Sorensen
Jun 1, 1954·Journal of Applied Physiology·P MEIER, K L ZIERLER
Mar 9, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M R SmithR Frayne
Sep 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Fernando CalamanteLars Kai Hansen

❮ Previous
Next ❯

Citations

Aug 16, 2013·AJNR. American Journal of Neuroradiology·B J ShinP C Sanelli
Sep 10, 2011·International Journal of Biomedical Imaging·Andreas FieselmannRebecca Fahrig
Jan 24, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kelvin K WongGeoffrey S Young
Aug 30, 2008·NMR in Biomedicine·L WillatsF Calamante
Jun 27, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter BruneckerJens Steinbrink
Dec 23, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Egbert J W BleekerMatthias J P van Osch
Jun 24, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jörg BrednoMax Wintermark
Jan 24, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Amit MehndirattaMichael A Chappell
Oct 3, 2013·Progress in Nuclear Magnetic Resonance Spectroscopy·Fernando Calamante
Feb 17, 2017·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michelle LivneJan Sobesky
Dec 29, 2019·International Journal for Numerical Methods in Biomedical Engineering·Timo KochDominik Obrist

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Fernando CalamanteLars Kai Hansen
Journal of Magnetic Resonance Imaging : JMRI
Cory LorenzAlma Gregory Sorensen
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
John J LeeJoshua S Shimony
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
L WillatsFernando Calamante
© 2021 Meta ULC. All rights reserved