PMID: 1209543Dec 15, 1975Paper

Calculation of predictive odds for possible carriers of heamophilia

Thrombosis Et Diathesis Haemorrhagica
C R PrenticeA D McLaren

Abstract

Betting odds for possible carriers of haemophilia have been calculated using data derived from normal and known carrier populations. For each possible carrier the concentration of factor VIII-related antigen and factor VIII biological activity was measured and used to determine the probability of the individual being a carrier. The calculations indicated that, of the 32 possible carriers, 11 were likely to be normal (odds of more than 5:1) while 11 were likely to be haemophilia carriers (again odds of more than 5:1).

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