PMID: 8949752Jan 1, 1996Paper

Calculation of RBE for normal tissue complications based on charged particle track structure

Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique
M Scholz

Abstract

A new approach for the calculation of relative biological effectiveness (RBE) for normal tissue complications after charged particle and neutron irradiation is discussed. It is based on the extension of a model originally developed for the application to cell survival. It can be shown that according to the model RBE values are determined largely by the alpha/beta-ratio of the photon dose response curve, but are expected to be nearly independent of the absolute values of alpha and beta. Thus the model can be applied to normal tissue complications as well, where alpha/beta- ratios can be determined by means of fractionation experiments. Agreement of model predictions and experimental results obtained in animal experiments confirm the applicability of the model even in the case of complex biological endpoints.

References

Jan 1, 1994·Radiation and Environmental Biophysics·M Krämer, G Kraft

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Citations

Jul 8, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·G Kraft
Apr 24, 2008·International Journal of Radiation Oncology, Biology, Physics·Thilo ElsässerMichael Scholz
Nov 2, 2015·Medical Physics·Sarah C BrüningkJan J Wilkens
Oct 21, 2003·Radiation Research·Jürgen DebusMichael Wannenmacher
Jan 1, 1997·Acta Oncologica·T ZachariasT Herrmann
Oct 8, 2003·Technology in Cancer Research & Treatment·M KrämerM Scholz
Oct 5, 2017·Physics in Medicine and Biology·Christian P Karger, Peter Peschke
Nov 14, 2018·Medical Physics·Piero FossatiChristian P Karger
Feb 12, 2021·Zeitschrift für medizinische Physik·Christian P KargerWilma Kraft-Weyrather

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