Calculation of trough:peak ratio of antihypertensive treatment from ambulatory blood pressure: methodological aspects
Abstract
To address several methodological questions related to calculation of trough:peak ratio from 24 h ambulatory blood pressure (BP) recordings. Data from patients with mild essential hypertension who were included in parallel group (n = 280) or cross-over studies (n = 39) were pooled. 24 h ambulatory BP recordings were available after 2- to 4-week washout from treatment and at the end of a 4- to 8-week period of treatment with calcium antagonists (n = 143), angiotensin converting enzyme inhibitors (n = 103) or placebo (73 patients from parallel group studies and 39 from a cross-over study). Each recording started between 0900 and 1000 h, immediately after the drug or placebo intake during the treatment phase. BP was measured at 15 min intervals during the day and at 15-20 min intervals during the night. Peak changes were calculated from systolic BP and diastolic BP 2-8 h after drug intake, and trough changes from readings taken during the last 4 h of the 24 h. Peak changes induced by drug treatment were progressively reduced when data were averaged over 1, 2, 4 and 6 h. BP reproducibility showed a concomitant increase and the best compromise between correct estimate of peak changes and reproducibility was the average of the adjace...Continue Reading
Citations
In Silico comparison between metoprolol succinate and bisoprolol on 24-hour systolic blood pressures
How to evaluate the duration of blood pressure control: the trough:peak ratio and 24-hour monitoring
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