PMID: 11920718Mar 29, 2002Paper

Calcyon in the rat brain: cloning of cDNA and expression of mRNA

The Journal of Comparative Neurology
Sergey ZeleninRochellys Diaz Heijtz

Abstract

Calcyon is a 24 kD protein recently cloned from a human brain cDNA library and shown to interact with the dopamine receptor 1 (D1R) of D1-like receptors. This interaction shifts the effector coupling of D1R to stimulate a calcium signaling pathway, without influencing the D1R-adenylyl-cAMP pathway. To obtain more knowledge about the potential role of calcyon in the brain, we cloned rat calcyon cDNA and studied its distribution in the brain. Northern blot analysis and RT-PCR revealed that rat calcyon mRNA was expressed only in the brain. With the use of the in situ hybridization technique, we studied rat calcyon mRNA distribution in the brain and related it to the distribution of D1R and dopamine receptor 5 (D5R) mRNAs. Prominent calcyon mRNA signals were found in several brain regions, including hippocampus, hypothalamus, cerebellum, and medial prefrontal cortex. Less abundant calcyon mRNA expression was observed in the dorsal striatum region, where D1R mRNA is highly expressed and where D1R/cAMP-DARPP-32 signaling pathway is of great functional importance. The strongest expression of D5R mRNA was found in the hippocampus and cerebellum, where D1R mRNA expression was relatively low. In conclusion, rat calcyon appears to be a br...Continue Reading

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Citations

Aug 29, 2003·Molecular and Cellular Endocrinology·J P ChangG Sawisky
Jul 11, 2003·Gene·Rujuan Dai, Clare Bergson
Sep 29, 2005·Pediatric Research·Lena ScottRochellys Diaz-Heijtz
Feb 23, 2010·European Journal of Pharmacology·Agata Faron-GóreckaMarta Dziedzicka-Wasylewska
Jun 10, 2008·Neuroscience Letters·László NégyessyPatricia S Goldman-Rakic
Feb 26, 2008·Behavioural Brain Research·Heather Trantham-DavidsonClare Bergson
Jun 26, 2007·Physiology & Behavior·Rochellys Diaz HeijtzHans Forssberg
Jan 6, 2009·The European Journal of Neuroscience·Heather Trantham DavidsonClare Bergson
Aug 7, 2004·Brain Research. Brain Research Reviews·Teige P SheehanDavid S Russell
Dec 4, 2003·The Journal of Comparative Neurology·Scott A Oakman, James H Meador-Woodruff
Feb 3, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xingguang LuoJoel Gelernter
Jun 21, 2006·Synapse·Karen L BaracskayJames H Meador-Woodruff
Sep 22, 2007·Neuroreport·Markus KruusmägiLena Scott

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