Caldora penicillata gen. nov., comb. nov. (cyanobacteria), a pantropical marine species with biomedical relevance

Journal of Phycology
Niclas EngeneV J Paul

Abstract

Many tropical marine cyanobacteria are prolific producers of bioactive secondary metabolites with ecological relevance and promising pharmaceutical applications. One species of chemically rich, tropical marine cyanobacteria that was previously identified as Symploca hydnoides or Symploca sp. corresponds to the traditional taxonomic definition of Phormidium penicillatum. In this study, we clarified the taxonomy of this biomedically and ecologically important cyanobacterium by comparing recently collected specimens with the original type material and the taxonomic description of P. penicillatum. Molecular phylogenetic analyses of the 16S rRNA gene and the 16S-23S internal transcribed spacer regions showed that P. penicillatum formed an independent clade sister to the genus Symploca, and distantly related to Phormidium and Lyngbya. We propose the new genus Caldora for this clade, with Caldora penicillata comb. nov. as the type species and designate as the epitype the recently collected strain FK13-1. Furthermore, the production of bioactive secondary metabolites among various geographically dispersed collections of C. penicillata showed that this species consistently produced the metabolite dolastatin 10 and/or the related compoun...Continue Reading

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Citations

Jul 6, 2016·Journal of Natural Products·Sarath P GunasekeraHendrik Luesch
Nov 1, 2016·Biomolecules & Therapeutics·Ulrike Lindequist
Mar 27, 2019·Journal of Biomolecular Structure & Dynamics·Varun DewakerYenamandra S Prabhakar
Jan 26, 2020·Toxins·Despoina KonstantinouSpyros Gkelis
Apr 3, 2020·Chembiochem : a European Journal of Chemical Biology·Ranjala RatnayakeHendrik Luesch
Jul 29, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xiao LiangHendrik Luesch
Dec 30, 2020·Marine Drugs·Conxita Avila, Carlos Angulo-Preckler
Feb 27, 2021·Journal of Natural Products·Kimberly S TaylorTakashi L Suyama
Apr 19, 2017·Bioorganic & Medicinal Chemistry·Bumki KimJiyong Hong
Jun 27, 2018·Journal of Natural Products·Yuki KanamoriKiyotake Suenaga
Feb 13, 2018·Journal of Natural Products·John H MillerPeter T Northcote
Nov 6, 2018·Journal of Natural Products·Arihiro IwasakiKiyotake Suenaga

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