Caliban's heritance and the genetics of neuronal aging

Trends in Neurosciences
Bruce Teter, Caleb E Finch

Abstract

Although current research on brain aging is dominated by Alzheimer's disease (AD), many other brain changes arise during middle age in humans and in rodent models that are independent of AD-like neurodegeneration. Differences and continuities between normal and pathological aspects of neuronal aging reveal the relative contributions and interactions of genetic and environmental factors. Apolipoprotein E alleles might be prototypes for genetic polymorphisms associated with functional changes that arise during middle age. Mice are valuable models for these aspects of aging because most genotypes show little neurodegeneration, and none accumulate beta-amyloid unless human transgenes are introduced. As further human genes are found to modify normal and pathological neuronal aging, this zoo of aging-animal variants will facilitate analysis both of pathways of age-related neuronal dysfunction and of environmental influences on these pathways.

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Sep 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J KaprioC F Sing
May 1, 1974·The Journal of Comparative Neurology·R D Monagle, H Brody
Mar 1, 1993·Trends in Neurosciences·C E Finch
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·D E SmithM H Tuszynski
Dec 22, 1999·Neurobiology of Aging·G M Martin
Apr 4, 2000·Nature·J RaberL Mucke
May 4, 2000·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·K P RileyN Nanayakkara
Jul 19, 2000·Biochimica Et Biophysica Acta·M A Boss
Feb 24, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·G B FrisoniM Trabucchi
Mar 7, 2001·Frontiers in Bioscience : a Journal and Virtual Library·S Fazio, M F Linton
Mar 16, 2001·Trends in Neurosciences·W L KleinC E Finch
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·K FlurkeyD E Harrison
May 8, 2002·International Journal of Geriatric Psychiatry·S ReevesR Howard
Jul 12, 2002·Journal of Neuroscience Research·B TeterG M Cole
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Matthew A WozniakUNKNOWN Trent HCV Study Group
Aug 29, 2002·Nature·Ian J DearyLawrence J Whalley
Oct 23, 2002·Journal of Neuroscience Research·Bruce Teter, J Wesson Ashford
Jun 13, 2003·Journal of Geriatric Psychiatry and Neurology·Linda M ErcoliGary W Small
Sep 26, 2003·The Journal of Biological Chemistry·John R LynchDaniel T Laskowitz
Nov 1, 2003·Science·James L KennedyPeter St George-Hyslop
Dec 12, 2003·Genetics·Joshua M Shulman, Mel B Feany

❮ Previous
Next ❯

Citations

Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lauren C LietsLeo M Chalupa
Feb 8, 2006·Postgraduate Medical Journal·R Peters
Dec 15, 2007·Molecular Diagnosis & Therapy·Ramón Cacabelos
Jun 11, 2005·Mechanisms of Ageing and Development·João Pedro de Magalhães, Anders Sandberg
Jul 27, 2006·Acta Neurologica Scandinavica. Supplementum·M Kivipelto, A Solomon
Nov 26, 2013·NeuroImage·R Matthew Hutchison, Stefan Everling
Jan 10, 2012·Journal of Affective Disorders·R SureshkumarM Varghese
Dec 7, 2011·Progress in Lipid Research·María Dolores LedesmaCarlos G Dotti
Apr 12, 2008·European Archives of Psychiatry and Clinical Neuroscience·Ramón Cacabelos
Jul 14, 2005·Journal of Neurochemistry·Sabine WellnitzChristian Czech

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Louis F Reichardt
Trends in Neurosciences
Alex VerkhratskyEmil C Toescu
© 2021 Meta ULC. All rights reserved