Calibrated integrated backscatter and myocardial fibrosis in patients undergoing cardiac surgery

Open Heart
David L PriorDuncan J Campbell

Abstract

The reported association between calibrated integrated backscatter (cIB) and myocardial fibrosis is based on study of patients with dilated or hypertrophic cardiomyopathy and extensive (mean 15-34%) fibrosis. Its association with lesser degrees of fibrosis is unknown. We examined the relationship between cIB and myocardial fibrosis in patients with coronary artery disease. Myocardial histology was examined in left ventricular epicardial biopsies from 40 patients (29 men and 11 women) undergoing coronary artery bypass graft surgery, who had preoperative echocardiography with cIB measurement. Total fibrosis (picrosirius red staining) varied from 0.7% to 4%, and in contrast to previous reports, cIB showed weak inverse associations with total fibrosis (r=-0.32, p=0.047) and interstitial fibrosis (r=-0.34, p=0.03). However, cIB was not significantly associated with other histological parameters, including immunostaining for collagens I and III, the advanced glycation end product (AGE) N(ε)-(carboxymethyl)lysine (CML) and the receptor for AGEs (RAGE). When biomarkers were examined, cIB was weakly associated with log plasma levels of amino-terminal pro-B-type natriuretic peptide (r=0.34, p=0.03), creatinine (r=0.33, p=0.04) and glomer...Continue Reading

Citations

Nov 16, 2019·Cardiovascular Ultrasound·Mohammed A MoharramSean Coffey
Feb 16, 2021·Current Problems in Cardiology·João AbecasisAna Félix
Sep 23, 2019·JACC. Cardiovascular Imaging·Theodoros D KaramitsosVanessa M Ferreira
Jul 2, 2021·Current Cardiology Reports·Nicola GaibazziGiovanna Di Giannuario
Aug 31, 2020·JACC. Cardiovascular Imaging·Sebastien SallesHans Torp

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Methods Mentioned

BETA
coronary artery bypass
biopsy
biopsies

Software Mentioned

EchoPAC
HOMA calculator
EchoPAC PC

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