Calibration of the shear wave speed-stress relationship in in situ Achilles tendons using cadaveric simulations of gait and isometric contraction.

Journal of Biomechanics
Jack MartinDarryl Thelen

Abstract

It has been shown that shear wave speed is directly dependent on axial stress in ex vivo tendons. Hence, a wave speed sensor could be used to track tendon loading during movement. However, adjacent soft tissues and varying joint postures may affect the wave speed-load relationship for intact tendons. The purpose of this study was to determine whether the proportional relationship between squared wave speed and stress holds for in situ cadaveric Achilles tendons, to evaluate whether this relationship is affected by joint angle, and to assess potential calibration techniques. Achilles tendon wave speed and loading were simultaneously measured during cadaveric simulations of gait and isometric contractions performed in a robotic gait simulator. Squared wave speed and axial stress were highly correlated during isometric contraction at all ankle postures (R2avg = 0.98) and during simulations of gait (R2avg = 0.92). Ankle plantarflexion angle did not have a consistent effect on the constant of proportionality (p = 0.217), but there was a significant specimen-angle interaction effect (p < 0.001). Wave speed-based predictions of tendon stress were most accurate (average RMS error = 11% of maximum stress) when calibrating to isometric c...Continue Reading

References

Mar 1, 1987·International Journal of Sports Medicine·P V KomiO Kokko
Apr 1, 1995·Ultrasonic Imaging·I CéspedesS Spratt
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·P V KomiJ R Lacour
Apr 16, 1998·European Journal of Applied Physiology and Occupational Physiology·T FinniJ Lukkariniemi
Aug 9, 2003·European Journal of Applied Physiology·S Peter Magnusson, Michael Kjaer
Apr 21, 2004·Annals of Biomedical Engineering·Braden C Fleming, Bruce D Beynnon
Oct 31, 2006·Clinical Biomechanics·Ahmet ErdemirAntonie J van den Bogert
Apr 5, 2011·Gait & Posture·Eric C WhittakerWilliam R Ledoux
Jul 10, 2012·Magnetic Resonance Imaging·Andriy FedorovRon Kikinis
Oct 9, 2012·Journal of Applied Physiology·Lauri StenrothTaija Finni
Feb 18, 2014·Acta Biomaterialia·Spencer E Szczesny, Dawn M Elliott
Feb 24, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Jaclyn Kondratko-MittnachtRay Vanderby
Apr 25, 2018·Nature Communications·Jack A MartinDarryl G Thelen
May 16, 2019·Journal of Biomechanics·Jack A MartinDarryl G Thelen
Sep 19, 2019·Scientific Reports·Emily M KeulerDarryl G Thelen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.