Calibration of thresholds for functional engagement of vagal A, B and C fiber groups in vivo

Bioelectronics in Medicine
Robin M McAllenJohn B Furness

Abstract

Vagal nerve stimulation is widely used therapeutically but the fiber groups activated are often unknown. To establish a simple protocol to define stimulus thresholds for vagal A, B and C fibers. The intact left or right cervical vagus was stimulated with 0.1 ms pulses in spontaneously breathing anesthetized rats. Heart and respiratory rate responses to vagal stimulation were recorded. The vagus was subsequently cut distally, and mass action potentials to the same stimuli were recorded. Stimulating at either 50 Hz for 2 s or 2 Hz for 10 s at experimentally determined strengths revealed A, B and C fiber thresholds that were related to respiratory and heart rate changes. Our simple protocol discriminates vagal A, B and C fiber thresholds in vivo.

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Citations

Jun 20, 2019·Journal of Neurophysiology·Michael S BorlandCrystal T Engineer
Jul 13, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi
Apr 9, 2019·Methods and Protocols·Manolo U RiosSeth A Hays
May 28, 2019·Frontiers in Neuroscience·Sophie C PayneJames B Fallon
Nov 19, 2019·PloS One·Jesse E BucksotSeth A Hays
Sep 26, 2019·Frontiers in Neuroscience·Crystal M NollerMark S Nash
Apr 2, 2020·Bioelectronic Medicine·Despοina NtiloudiStavros Zanos
Jun 10, 2020·Scientific Reports·Umair AhmedStavros Zanos
Sep 10, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toru KawadaMasaru Sugimachi
Dec 1, 2020·Frontiers in Neuroscience·Nicole A PelotWarren M Grill
Nov 21, 2020·Brain Stimulation·Lindsea C BoothAlexander V Gourine
Dec 22, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rimenez R SouzaMichael P Kilgard
Jun 11, 2021·Frontiers in Neuroscience·Adam FitchettKirill Aristovich
Aug 19, 2021·Journal of Neural Engineering·S BowlesC G Welle
Dec 21, 2021·Frontiers in Neuroscience·Alexandre BergerRiëm El Tahry

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