Jun 2, 2020

Calixarene-mediated assembly of water-soluble C60 -attached ultrathin graphite hybrids for efficient activation of reactive oxygen species to treat neuroblastoma cells

Chemical Communications : Chem Comm
Jingxin MoQinghua Li


Unprecedented nano-carbon hybrids consisting of exfoliated ultrathin graphite (or single-walled carbon nanotubes) with pristine C60 molecules attached on the surfaces have been produced in water in the presence of p-phosphonic acid calix[8]arene. The amphiphilic calixarene plays multiple roles in these processes to provide water dispersibility and π-π interactions with flexible conformations complementing curvatures of the carbon surfaces. The significantly increased water solubility and area of exposure of C60 enable efficient activation of reactive oxygen species for enhanced phototoxicity to SH-SY5Y human neuroblastoma cell line under laser irradiation.

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Mentioned in this Paper

Water soluble vitamin product
Phosphonous Acids
Nanotubes, Carbon
Natural graphite
Reactive Oxygen Species

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