Callosal tissue loss in multiple system atrophy--a one-year follow-up study.

Movement Disorders : Official Journal of the Movement Disorder Society
Martina MinneropThomas Klockgether

Abstract

Multiple system atrophy (MSA) is a neurodegenerative disease not only affecting the basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord but also the cerebral cortex. Clinically, cerebellar (MSA-C) and parkinsonian variants of MSA (MSA-P) are distinguished. We investigated 14 MSA patients (10 MSA-C, 4 MSA-P, men: 7, women: 7; age: 61.1 ± 3.3 years) and 14 matched controls (men: 7, women: 7; age: 58.6 ± 5.1 years) with voxel-based morphometry (VBM) to analyze gray and white matter differences both at baseline and at follow-up, 1 year later. Baseline comparisons between patients and controls confirmed significantly less gray matter in MSA in the cerebellum and cerebral cortex, and significantly less white matter in the cerebellar peduncles and brainstem. Comparisons of tissue-loss profiles (i.e., baseline versus follow-up) between patients and controls, revealed white matter reduction in MSA along the middle cerebellar peduncles, reflecting degeneration of the ponto-cerebellar tract as a particularly prominent and progressive morphological alteration in MSA. Comparisons between baseline and follow-up, separately performed in patients and controls, revealed additional white matter reduction i...Continue Reading

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Citations

Sep 15, 2014·Neurobiology of Aging·Jieqiong ChenMichael Janitz
Nov 11, 2014·The Cerebellum·Leonardo BaldarçaraChristophe Habas
Oct 26, 2016·Journal of Neural Transmission·Eleonora FiorenzatoUNKNOWN Movement Disorders Society MSA (MODIMSA) Neuropsychology and Imaging Study Groups
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Feb 15, 2019·Scientific Reports·Miriam MenzelKristel Michielsen
May 18, 2011·Current Opinion in Neurology·Gregor K WenningWerner Poewe
Jul 28, 2016·Movement Disorders Clinical Practice·Han-Joon KimVictor S C Fung

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