Calmodulin: A Multitasking Protein in Kv7.2 Potassium Channel Functions

Biomolecules
Alessandro Alaimo, Alvaro Villarroel

Abstract

The ubiquitous calcium transducer calmodulin (CaM) plays a pivotal role in many cellular processes, regulating a myriad of structurally different target proteins. Indeed, it is unquestionable that CaM is the most relevant transductor of calcium signals in eukaryotic cells. During the last two decades, different studies have demonstrated that CaM mediates the modulation of several ion channels. Among others, it has been indicated that Kv7.2 channels, one of the members of the voltage gated potassium channel family that plays a critical role in brain excitability, requires CaM binding to regulate the different mechanisms that govern its functions. The purpose of this review is to provide an overview of the most recent advances in structure⁻function studies on the role of CaM regulation of Kv7.2 and the other members of the Kv7 family.

References

Jan 1, 1988·Ion Channels·D A Brown
Feb 6, 1970·Biochemical and Biophysical Research Communications·W Y Cheung
Jan 1, 1970·Advances in Biochemical Psychopharmacology·W Y Cheung
Aug 22, 1994·FEBS Letters·Y Saimi, C Kung
Jan 1, 1997·Annual Review of Physiology·N V Marrion
Apr 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A R Rhoads, F Friedberg
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·H CruzblancaB Hille
Jul 3, 1999·Physiological Reviews·L A JuradoH W Jarrett
Jul 8, 2000·Trends in Cell Biology·D Chin, A R Means
Mar 17, 2001·Nature Reviews. Neuroscience·T J Jentsch
Jul 13, 2001·Pharmacology & Therapeutics·J Robbins
Feb 5, 2002·Annual Review of Physiology·Yoshiro Saimi, Ching Kung
Jan 25, 2003·European Journal of Biochemistry·Stefan W Vetter, Estelle Leclerc
Jun 18, 2003·The Journal of General Physiology·Nikita Gamper, Mark S Shapiro
Apr 2, 2005·Nature Reviews. Neuroscience·Zhengui Xia, Daniel R Storm
May 20, 2005·Molecular Biology of the Cell·Nikita GamperMark S Shapiro
Oct 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yang LiMark S Shapiro
Nov 2, 2005·Nature Reviews. Neuroscience·Patrick Delmas, David A Brown
Nov 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mohammad ShahidullahIrwin B Levitan
Sep 23, 2006·Science·Byung-Chang SuhBertil Hille
Aug 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Oleg ZaikaMark S Shapiro
Nov 13, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ainhoa EtxeberriaAlvaro Villarroel
Jan 1, 2008·The Journal of Biological Chemistry·Reuven WienerJoel A Hirsch
Jan 26, 2008·The Journal of Physiology·Yoni Haitin, Bernard Attali
Mar 15, 2008·The Journal of Physiology·Manjot BalMark S Shapiro
Jun 6, 2009·The Journal of Biological Chemistry·Alessandro AlaimoAlvaro Villarroel
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adi EtzioniIlana Lotan
Oct 8, 2011·PloS One·Juan Camilo Gómez-PosadaAlvaro Villarroel
Aug 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Karen MrukWilliam R Kobertz

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Citations

Jan 24, 2020·The Journal of Pharmacology and Experimental Therapeutics·Zizhen WuQing Yang
Feb 23, 2020·International Journal of Molecular Sciences·Eider NúñezAlvaro Villarroel
Oct 8, 2020·Current Opinion in Cardiology·Susan P Etheridge, Mary C Niu
Mar 24, 2021·Expert Opinion on Therapeutic Targets·E S Nikitin, L V Vinogradova

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Methods Mentioned

BETA
FRET
nuclear magnetic resonance
X-ray
NMR

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